INT354959

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Context Info
Confidence 0.27
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.11
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Shank3) cytoplasm (Shank3)
Anatomy Link Frequency
proximal 4
Shank3 (Mus musculus)
Pain Link Frequency Relevance Heat
Neurobehavioral 8 65.04 Quite High
long-term potentiation 46 5.00 Very Low Very Low Very Low
depression 14 5.00 Very Low Very Low Very Low
imagery 10 5.00 Very Low Very Low Very Low
Glutamate receptor 8 5.00 Very Low Very Low Very Low
Pyramidal cell 6 5.00 Very Low Very Low Very Low
nMDA receptor 4 5.00 Very Low Very Low Very Low
Hippocampus 4 5.00 Very Low Very Low Very Low
tetrodotoxin 2 5.00 Very Low Very Low Very Low
nMDA receptor antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 30 96.96 Very High Very High Very High
Targeted Disruption 14 94.52 High High
Schizophrenia 4 82.88 Quite High
Asperger Syndrome 2 76.20 Quite High
Mental Disorders 4 60.88 Quite High
Autism 6 50.00 Quite Low
Cognitive Disorder 4 18.48 Low Low
Cytomegalovirus Infection 2 5.04 Very Low Very Low Very Low
Depression 14 5.00 Very Low Very Low Very Low
Li-fraumeni Syndrome 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We focused on synaptic biology and synaptic function as the most proximal target for altered Shank3 expression.
Regulation (altered) of Gene_expression (expression) of Shank3 in proximal
1) Confidence 0.27 Published 2010 Journal Mol Autism Section Body Doc Link PMC3019144 Disease Relevance 0.55 Pain Relevance 0.03
We focused on synaptic biology and synaptic function as the most proximal target for altered Shank3 expression.
Regulation (target) of Gene_expression (expression) of Shank3 in proximal
2) Confidence 0.27 Published 2010 Journal Mol Autism Section Body Doc Link PMC3019144 Disease Relevance 0.56 Pain Relevance 0.03

General Comments

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