INT354969

Context Info Confidence 0.01 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.09 Pain Relevance 0

plasma membrane (Rapsn, Psd) cytoplasm (Rapsn, Psd) Golgi apparatus (Rapsn) intracellular (Psd) cytoskeleton (Rapsn)

Anatomy Link Frequency synapse 1 Rapsn (Mus musculus) Psd (Mus musculus)

Pain Link Frequency Relevance Heat Glutamate receptor 4 47.04 long-term potentiation 23 5.00 depression 7 5.00 imagery 5 5.00 Neurobehavioral 4 5.00 Pyramidal cell 3 5.00 nMDA receptor 2 5.00 Hippocampus 2 5.00 tetrodotoxin 1 5.00 nMDA receptor antagonist 1 5.00

Disease Link Frequency Relevance Heat Syndrome 15 89.80 Autism 3 50.00 Depression 7 5.00 Targeted Disruption 7 5.00 Li-fraumeni Syndrome 6 5.00 Schizophrenia 2 5.00 Cognitive Disorder 2 5.00 Mental Disorders 2 5.00 Aggression 1 5.00 Shock 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

GKAP is a PSD-95-binding protein that forms an important component of the postsynaptic density (PSD), where protein-protein interactions between scaffolding proteins and receptors are a key mechanism in assembling a functional synapse [2].

postsynaptic density Binding (forms) of PSD in synapse

1) Confidence 0.01 Published 2010 Journal Mol Autism Section Body Doc Link PMC3019144 Disease Relevance 0.09 Pain Relevance 0

General Comments

This test has worked.