INT3550

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 1975
Last Reported 2010
Negated 0
Speculated 3
Reported most in Abstract
Documents 52
Total Number 56
Disease Relevance 33.93
Pain Relevance 5.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (GLA) extracellular region (GLA) Golgi apparatus (GLA)
lysosome (GLA) cytoplasm (GLA)
Anatomy Link Frequency
plasma 3
leukocyte 3
nerves 2
body 2
muscle 1
GLA (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropathic pain 31 100.00 Very High Very High Very High
Analgesic 13 99.64 Very High Very High Very High
Pain 145 99.28 Very High Very High Very High
tolerance 8 98.96 Very High Very High Very High
Lasting pain 7 97.40 Very High Very High Very High
cva 32 96.32 Very High Very High Very High
positron emission tomography 6 94.56 High High
neuralgia 1 82.32 Quite High
Acute pain 4 81.68 Quite High
antagonist 2 78.88 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 44 100.00 Very High Very High Very High
Disorders Of Creatine Metabolism 8 100.00 Very High Very High Very High
Fabry Disease 639 99.96 Very High Very High Very High
Disease 218 99.96 Very High Very High Very High
Chronic Renal Failure 40 99.84 Very High Very High Very High
Lysosomal Storage Diseases 19 99.78 Very High Very High Very High
Inborn Error Of Metabolism 5 99.70 Very High Very High Very High
Lysosome Storage Disease 39 99.60 Very High Very High Very High
Telangiectasia 8 99.44 Very High Very High Very High
Pain 147 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Deficiency in the lysosomal enzyme alpha-galactosidase (alpha-GAL) causes an accumulation of its substrate, which ultimately leads to Fabry disease symptoms.
Negative_regulation (Deficiency) of lysosomal enzyme alpha-galactosidase associated with fabry disease
1) Confidence 0.59 Published 2004 Journal J. Mol. Biol. Section Abstract Doc Link 15003450 Disease Relevance 0.46 Pain Relevance 0.10
Fabry disease is an X-linked lysosomal storage disease caused by deficiency of the enzyme alpha-galactosidase A and results in pain, progressive renal impairment, cardiomyopathy, and cerebrovascular disease.
Negative_regulation (deficiency) of alpha-galactosidase associated with cerebrovascular disease, pain, lysosomal storage diseases, fabry disease and coronary heart disease
2) Confidence 0.59 Published 2005 Journal Mol. Neurobiol. Section Abstract Doc Link 16077182 Disease Relevance 0.63 Pain Relevance 0.16
In a 35-year-old man with the full picture of Fabry's disease there was an almost fourfold increase of trihexosylceramide concentration in plasma and a decrease in the alpha-galactosidase activity to 13 percent as compared with the values from a control group.
Negative_regulation (decrease) of alpha-galactosidase in plasma associated with fabry disease and disease
3) Confidence 0.59 Published 1975 Journal Dtsch. Med. Wochenschr. Section Abstract Doc Link 803896 Disease Relevance 0.42 Pain Relevance 0.07
His mother had and decreased alpha-galactosidase activity which levels showed between normal and patient and was speculated to be a carrier.
Negative_regulation (decreased) of alpha-galactosidase
4) Confidence 0.59 Published 1980 Journal No To Shinkei Section Abstract Doc Link 6245668 Disease Relevance 0.55 Pain Relevance 0.14
RESULTS: Clinical evaluation suggested the diagnosis of Fabry disease, which was confirmed by reduced plasma and leukocyte alpha-galactosidase A activities (8.8% and 13.4% of normal, respectively) due to a missense A143T mutation.
Negative_regulation (reduced) of alpha-galactosidase in plasma
5) Confidence 0.59 Published 2006 Journal Arch. Neurol. Section Body Doc Link 16533976 Disease Relevance 0.08 Pain Relevance 0
Anderson-Fabry disease is a rare inherited X-linked lysosomal storage disease caused by deficiency of the enzyme alpha-galactosidase A.
Negative_regulation (deficiency) of alpha-galactosidase associated with lysosomal storage diseases and fabry disease
6) Confidence 0.58 Published 2006 Journal Acta Med Croatica Section Abstract Doc Link 16802573 Disease Relevance 0.59 Pain Relevance 0.12
The deficiency of alpha-galactosidase activity leads to progressive, abnormal accumulation of neutral glycosphingolipids in the lysosome.
Negative_regulation (deficiency) of alpha-galactosidase
7) Confidence 0.58 Published 2006 Journal Acta Med Croatica Section Abstract Doc Link 16802573 Disease Relevance 0.65 Pain Relevance 0.12
Their mother had diminished alpha-galactosidase activity and several angiomatous papules on one breast.
Negative_regulation (diminished) of alpha-galactosidase in papules
8) Confidence 0.57 Published 1995 Journal Pediatr Dermatol Section Abstract Doc Link 7501549 Disease Relevance 1.14 Pain Relevance 0.24
Both had an absence of alpha-galactosidase.
Negative_regulation (absence) of alpha-galactosidase
9) Confidence 0.57 Published 1995 Journal Pediatr Dermatol Section Abstract Doc Link 7501549 Disease Relevance 1.11 Pain Relevance 0.26
OBJECTIVE: To determine the significance of the dermatologic and systemic abnormalities found in 11 patients with Fabry disease (FD) which is an X-linked lysosomal storage disorder caused by the partial or complete deficiency of the alpha-galactosidase A enzyme.
Spec (partial) Negative_regulation (deficiency) of alpha-galactosidase A associated with congenital anomalies, fabry disease and lysosome storage disease
10) Confidence 0.57 Published 2004 Journal Arch Dermatol Section Abstract Doc Link 15611419 Disease Relevance 0.37 Pain Relevance 0
BACKGROUND: Fabry disease is an X-linked lysosomal storage disease caused by deficiency of alpha-galactosidase A (alpha-Gal A), encoded by the GLA gene.
Negative_regulation (deficiency) of alpha-galactosidase A associated with lysosomal storage diseases and fabry disease
11) Confidence 0.57 Published 2009 Journal Expert Opin Biol Ther Section Abstract Doc Link 19368525 Disease Relevance 0.62 Pain Relevance 0.09
BACKGROUND: Fabry-Anderson disease is an x-linked deficiency of lysosomal alpha-galactosidase A (GALA), resulting in chronic renal failure, cardiac arrhythmia, hypertrophy, valvular disease, pain (acro-paraesthesiae) and stroke, together with premature mortality.
Negative_regulation (deficiency) of GALA associated with pain, hypertrophy, chronic renal failure, stroke, arrhythmia under development, fabry disease and disease
12) Confidence 0.57 Published 2007 Journal Pharmacoeconomics Section Abstract Doc Link 17335306 Disease Relevance 1.01 Pain Relevance 0.10
Fabry disease is a rare inherited lysosomal storage disorder caused by the partial or complete deficiency of the lysosomal enzyme alpha galactosidase A (alpha-Gal A), resulting in excess cellular glycosphingolipid deposition.
Spec (partial) Negative_regulation (deficiency) of alpha-Gal A associated with fabry disease and lysosome storage disease
13) Confidence 0.57 Published 2009 Journal Cardiol Rev Section Abstract Doc Link 19092368 Disease Relevance 0.53 Pain Relevance 0.06
Fabry disease is an inherited X-linked lysosomal storage disease due to a genetic defect of the GLA gene which encodes the protein of the enzyme alpha-galaktosidase A.
Negative_regulation (defect) of GLA associated with lysosomal storage diseases and fabry disease
14) Confidence 0.57 Published 2007 Journal Dtsch. Med. Wochenschr. Section Abstract Doc Link 17940933 Disease Relevance 0.40 Pain Relevance 0.06
The clinical spectrum of Fabry disease, an X-linked lysosomal storage disorder due to alpha-galactosidase A (alpha-Gal A) deficiency, has been expanded beyond the classic phenotype to include the recently recognized later-onset "cardiac" and "renal" variants.
Negative_regulation (deficiency) of alpha-Gal A associated with fabry disease and lysosome storage disease
15) Confidence 0.57 Published 2006 Journal Nephrol. Ther. Section Abstract Doc Link 17373219 Disease Relevance 0.68 Pain Relevance 0.12
The mechanisms by which alpha-galactosidase A deficiency causes these physiological abnormalities are poorly understood.
Negative_regulation (deficiency) of alpha-galactosidase A associated with congenital anomalies
16) Confidence 0.57 Published 2002 Journal Acta Paediatr Suppl Section Abstract Doc Link 12572843 Disease Relevance 1.14 Pain Relevance 0.70
Demonstration of alpha-galactosidase A deficiency in leukocytes or plasma is the definitive method for the diagnosis of affected hemizygous males.
Negative_regulation (deficiency) of alpha-galactosidase A in plasma
17) Confidence 0.57 Published 2002 Journal J. Soc. Biol. Section Abstract Doc Link 12360745 Disease Relevance 1.03 Pain Relevance 0.18
Deficiency in the lysosomal enzyme alpha-galactosidase (alpha-GAL) causes an accumulation of its substrate, which ultimately leads to Fabry disease symptoms.
Negative_regulation (Deficiency) of alpha-GAL associated with fabry disease
18) Confidence 0.51 Published 2004 Journal J. Mol. Biol. Section Abstract Doc Link 15003450 Disease Relevance 0.46 Pain Relevance 0.10
Fabry's disease is a rare, X-linked disorder of the glycosphingolipid metabolism, in which a partial or total deficiency of a lysosomal alpha(alpha)-galactosidase results in the progressive accumulation of neutral glycosphingolipids with terminal alpha galactose moieties (i.e., cerebroside di- and trihexoside) in most body fluids and tissues.
Spec (partial) Negative_regulation (deficiency) of galactosidase in body associated with disease
19) Confidence 0.51 Published 1998 Journal Yonsei Med. J. Section Abstract Doc Link 9529988 Disease Relevance 0.40 Pain Relevance 0.05
He was made diagnosis of Fabry's disease by laboratory examinations which were alpha-galactosidase deficiency analysed in leukocytes, increased ceramide trihexosides demonstrated in urinary sediment and electron microscopic findings in the biopsy of the skin and sural nerve.
Negative_regulation (deficiency) of alpha-galactosidase in nerve associated with disease
20) Confidence 0.43 Published 1980 Journal No To Shinkei Section Abstract Doc Link 6245668 Disease Relevance 0.59 Pain Relevance 0.16

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox