INT355015

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Context Info
Confidence 0.21
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.47
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mbp)
Anatomy Link Frequency
neuronal 1
Mbp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Demyelination 12 99.34 Very High Very High Very High
metalloproteinase 10 98.96 Very High Very High Very High
Spinal cord 42 82.72 Quite High
cytokine 14 79.56 Quite High
Nerve growth factor 16 73.72 Quite High
Inflammation 8 24.12 Low Low
ischemia 6 12.84 Low Low
Neuropathic pain 2 10.72 Low Low
Central nervous system 22 5.00 Very Low Very Low Very Low
Glutamate 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Demyelinating Disease 20 99.92 Very High Very High Very High
Spinal Cord Injury 126 98.80 Very High Very High Very High
Death 16 98.28 Very High Very High Very High
Apoptosis 24 84.68 Quite High
Injury 100 70.80 Quite High
Cicatrix 44 64.92 Quite High
Leukemia 2 44.88 Quite Low
Necrosis 6 34.80 Quite Low
Cancer 12 34.44 Quite Low
INFLAMMATION 10 24.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TPA’s mechanism of action strongly suggests that it has a possible role in secondary SCI by promoting demyelination through plasmin, which directly degrades MBP and initiates the matrix metalloproteinase (MMP) cascade known to play an important role in the breakdown of myelin sheaths.
Protein_catabolism (degrades) of MBP associated with demyelination, spinal cord injury and metalloproteinase
1) Confidence 0.21 Published 2010 Journal Surgical Neurology International Section Body Doc Link PMC3019362 Disease Relevance 1.28 Pain Relevance 0.32
TPA, a serine protease and a well-recognized thrombolytic agent, is considered to be involved in demyelinating diseases by degrading myelin basic protein (MBP) and contributing to excitotoxic neuronal death by activating microglia.
Protein_catabolism (degrading) of MBP in neuronal associated with demyelinating disease and death
2) Confidence 0.21 Published 2010 Journal Surgical Neurology International Section Body Doc Link PMC3019362 Disease Relevance 1.19 Pain Relevance 0.29

General Comments

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