INT355038

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.23
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (NRP1, CKAP4) cell differentiation (NRP1) endoplasmic reticulum (CKAP4)
cytoplasm (CKAP4) cell-cell signaling (NRP1) cytosol (NRP1)
Anatomy Link Frequency
bladder 1
NRP1 (Homo sapiens)
CKAP4 (Homo sapiens)
Pain Link Frequency Relevance Heat
interstitial cystitis 6 100.00 Very High Very High Very High
metalloproteinase 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Interstitial Cystitis 6 100.00 Very High Very High Very High
Bladder Cancer 32 88.80 High High
Disease 2 77.16 Quite High
Metastasis 3 74.52 Quite High
Cancer 7 73.44 Quite High
Congenital Anomalies 1 62.64 Quite High
Carcinoma 2 52.36 Quite High
Malignant Neoplastic Disease 4 33.40 Quite Low
Retinoblastoma 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
APF is a low molecular weight frizzled 8-related glycopeptide that inhibits both normal and IC bladder epithelial cell proliferation via cytoskeleton associated protein 4 (CKAP4, also known as CLIMP-63 and ERGIC-63) [27], a type II transmembrane receptor [28] whose palmitoylation appears to be required for mediating APF activity in HeLa cells [29].
transmembrane receptor Negative_regulation (inhibits) of CKAP4 in bladder associated with interstitial cystitis
1) Confidence 0.02 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3020166 Disease Relevance 1.23 Pain Relevance 0.29

General Comments

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