INT355082

Context Info Confidence 0.01 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.25 Pain Relevance 0

extracellular space (GREM1) extracellular region (GREM1) cell-cell signaling (GREM1)

GREM1 (Homo sapiens)

Pain Link Frequency Relevance Heat interstitial cystitis 6 5.00 metalloproteinase 3 5.00

Disease Link Frequency Relevance Heat Bladder Cancer 32 90.52 Malignant Neoplastic Disease 4 77.64 Cancer 7 5.00 Interstitial Cystitis 6 5.00 Metastasis 3 5.00 Disease 2 5.00 Carcinoma 2 5.00 Retinoblastoma 1 5.00 Congenital Anomalies 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

activity is reduced by phosphorylation of ser9 but stimulated by phosphorylation on tyr216 [42], and the downstream effects of Akt activation/phosphorylation during Wnt/frizzled signaling include increased ser9 phosphorylation with decreased activity of GSK3?

Positive_regulation (increased) of Phosphorylation (phosphorylation) of increased

1) Confidence 0.01 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3020166 Disease Relevance 0.25 Pain Relevance 0

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