INT355099

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Context Info
Confidence 0.44
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.83
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins2) extracellular region (Ins2) nucleus (Ins2)
carbohydrate metabolic process (Ins2) cytoplasm (Ins2)
Anatomy Link Frequency
beta cells 1
Ins2 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 13 63.96 Quite High
alcohol 5 5.00 Very Low Very Low Very Low
beta blocker 1 5.00 Very Low Very Low Very Low
Nicotine 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 11 98.54 Very High Very High Very High
Aging 5 88.12 High High
Diabetes Mellitus 22 83.84 Quite High
Impaired Glucose Tolerance 13 63.96 Quite High
Nicotine Addiction 8 5.00 Very Low Very Low Very Low
Obesity 6 5.00 Very Low Very Low Very Low
Disorder Of Lipid Metabolism 5 5.00 Very Low Very Low Very Low
Osteoporosis 2 5.00 Very Low Very Low Very Low
Prediabetic State 2 5.00 Very Low Very Low Very Low
Hyperinsulinism 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although proinsulin levels increase together with insulin concentrations in insulin resistance [8], a raised ratio of proinsulin to insulin, due to a disproportionate release of proinsulin from beta cells, is considered an early marker of islet dysfunction [4].
Localization (release) of proinsulin in beta cells associated with insulin resistance
1) Confidence 0.44 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC3020169 Disease Relevance 0.83 Pain Relevance 0.09

General Comments

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