INT355200

Context Info Confidence 0.14 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.77 Pain Relevance 0

nucleus (HDAC9) transcription factor binding (HDAC9) cytoplasm (HDAC9)

HDAC9 (Homo sapiens)

Pain Link Frequency Relevance Heat dexamethasone 8 5.00 Potency 6 5.00 cytokine 4 5.00 palliative 2 5.00 Inflammation 2 5.00 tolerance 2 5.00 Antiemetics 2 5.00 cva 2 5.00

Disease Link Frequency Relevance Heat Cancer 110 99.66 Hematologic Neoplasms 28 97.28 Colon Cancer 8 93.12 Endometriosis (extended) 2 89.64 Apoptosis 10 87.52 Genetic Translocation 2 87.12 Disease 74 82.80 Metastasis 6 82.32 Repression 4 80.76 Acute Promyelocytic Leukemia 2 71.20

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Various studies in cancer cell lines and tumor tissue revealed changes in the acetylation levels and the expression of the HDAC enzymes (Bolden et al. 2006).

Regulation (changes) of Gene_expression (expression) of HDAC associated with cancer

1) Confidence 0.14 Published 2010 Journal Clinical Epigenetics Section Body Doc Link PMC3020651 Disease Relevance 0.93 Pain Relevance 0

Effects of HDAC inhibition

Regulation (Effects) of Gene_expression (inhibition) of HDAC

2) Confidence 0.09 Published 2010 Journal Clinical Epigenetics Section Body Doc Link PMC3020651 Disease Relevance 0.84 Pain Relevance 0

General Comments

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