INT355213

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Context Info
Confidence 0.29
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.34
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Tjp1) plasma membrane (Tjp1) nucleus (Tjp1)
cytoplasm (Tjp1)
Anatomy Link Frequency
brain 2
Tjp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 15 73.56 Quite High
Intracerebroventricular 3 58.92 Quite High
Central nervous system 12 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Multiple sclerosis 3 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 6 82.08 Quite High
Brain Hemorrhage 6 73.56 Quite High
Targeted Disruption 3 54.84 Quite High
Cv General 4 Under Development 6 37.80 Quite Low
Stress 6 16.00 Low Low
Hypoxia 9 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 9 5.00 Very Low Very Low Very Low
Brain Injury 9 5.00 Very Low Very Low Very Low
Brain Tumor 6 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data provides evidence that focused ultrasound in the presence of circulating ultrasound contrast agents (microbubbles) disrupts the interaction of tight junction proteins (occludin and ZO-1), thus affecting the integrity of the BBB.
Negative_regulation (disrupts) of ZO-1 Binding (interaction) of
1) Confidence 0.29 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0.27 Pain Relevance 0.06
Given that the phosphorylation of the proteins is an immediate event and the disruption of the BBB also occurs shortly after sonication, it is plausible that the ultrasound-mediated diminished interaction of occludin and ZO-1 is due to alteration in phosphorylation level of tight junction proteins.
Negative_regulation (diminished) of ZO-1 Binding (interaction) of
2) Confidence 0.29 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0.07 Pain Relevance 0.04
However, using immunoprecipitation analysis we show that the interaction of occludin and ZO-1 is reduced in the brain regions treated with ultrasound (Figure 3B).


Negative_regulation (reduced) of ZO-1 Binding (interaction) of in brain
3) Confidence 0.29 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0 Pain Relevance 0

General Comments

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