INT355220

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Context Info
Confidence 0.21
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.14
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ocln, Tjp1) cytoplasm (Ocln, Tjp1) cytosol (Ocln)
Golgi apparatus (Tjp1) nucleus (Tjp1)
Anatomy Link Frequency
brain 2
Ocln (Rattus norvegicus)
Tjp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 3 45.52 Quite Low
ketamine 3 42.40 Quite Low
cva 3 40.56 Quite Low
ischemia 15 37.84 Quite Low
Central nervous system 12 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Intracerebroventricular 3 5.00 Very Low Very Low Very Low
Multiple sclerosis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 3 79.12 Quite High
Stroke 3 58.12 Quite High
Hypoxia 9 45.40 Quite Low
Brain Injury 9 41.32 Quite Low
Cv General 4 Under Development 6 40.56 Quite Low
Cv Unclassified Under Development 6 37.84 Quite Low
Alzheimer's Dementia 9 37.20 Quite Low
Brain Hemorrhage 6 5.00 Very Low Very Low Very Low
Stress 6 5.00 Very Low Very Low Very Low
Brain Tumor 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Diminished interaction of Zo-1 with occludin in response to ultrasound
Negative_regulation (Diminished) of occludin Binding (interaction) of Zo-1
1) Confidence 0.21 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0 Pain Relevance 0
In the following study we show that the application of focused ultrasound in combination with ultrasound contrast agent disrupts the BBB integrity, and that this disruption is associated with reduced interaction of the tight junction protein occludin with ZO-1.
Negative_regulation (reduced) of occludin Binding (interaction) of ZO-1
2) Confidence 0.16 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0.14 Pain Relevance 0
However, using immunoprecipitation analysis we show that the interaction of occludin and ZO-1 is reduced in the brain regions treated with ultrasound (Figure 3B).


Negative_regulation (reduced) of occludin Binding (interaction) of ZO-1 in brain
3) Confidence 0.16 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0 Pain Relevance 0

General Comments

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