INT35536

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Context Info
Confidence 0.57
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 26
Total Number 26
Disease Relevance 14.39
Pain Relevance 5.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CAT) small molecule metabolic process (CAT) aging (CAT)
Golgi apparatus (CAT) endoplasmic reticulum (CAT) peroxisome (CAT)
Anatomy Link Frequency
erythrocyte 1
liver 1
brain 1
platelet 1
blood 1
CAT (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 20 99.52 Very High Very High Very High
Endep 11 99.24 Very High Very High Very High
fluoxetine 8 99.24 Very High Very High Very High
addiction 10 99.16 Very High Very High Very High
psoriasis 63 98.92 Very High Very High Very High
antidepressant 14 98.48 Very High Very High Very High
qutenza 9 98.48 Very High Very High Very High
Desipramine 2 97.04 Very High Very High Very High
medulla 1 90.80 High High
Serotonin 5 90.44 High High
Disease Link Frequency Relevance Heat
Cancer 40 100.00 Very High Very High Very High
Metastasis 1 100.00 Very High Very High Very High
Infection 29 99.92 Very High Very High Very High
Pulmonary Disease 100 99.84 Very High Very High Very High
Adenocarcinoma 45 99.84 Very High Very High Very High
Morphine Dependence 10 99.52 Very High Very High Very High
Skin Cancer 3 99.20 Very High Very High Very High
Psoriasis 106 98.92 Very High Very High Very High
Apoptosis 40 98.84 Very High Very High Very High
Stress 207 98.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was no complete or partial remission; however, 2 patients responded with minor tumor regression up to 32 weeks documented by reduction of liver metastases and primary tumor in CAT scan.
Negative_regulation (reduction) of CAT in liver associated with cancer and metastasis
1) Confidence 0.57 Published 1988 Journal Int. J. Cancer Suppl. Section Abstract Doc Link 3162451 Disease Relevance 0.92 Pain Relevance 0.07
Dursun, et al.44 reported decreased CAT activity in patients with esophageal and gastric cancer compared with controls.
Negative_regulation (decreased) of CAT associated with stomach cancer
2) Confidence 0.57 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2768243 Disease Relevance 0.79 Pain Relevance 0
RESULTS: The obtained results indicate a significant decrease in the activity of SOD1, CAT and GSHP-x, as well as in MDA concentration after the combined therapy.
Negative_regulation (decrease) of CAT
3) Confidence 0.57 Published 2009 Journal Hum Psychopharmacol Section Body Doc Link 19319921 Disease Relevance 0.07 Pain Relevance 0
Significant losses in CAT activity were observed only with the elimination of 2 NF-kappa B sites, located -269 and -809 bp upstream from the translational start site, respectively.
Negative_regulation (losses) of CAT
4) Confidence 0.57 Published 1997 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9425310 Disease Relevance 0.17 Pain Relevance 0.11
A decreased in catalase protein levels has been also observed.
Negative_regulation (decreased) of catalase
5) Confidence 0.52 Published 2008 Journal Toxicology Section Abstract Doc Link 17980474 Disease Relevance 0.21 Pain Relevance 0.44
In order to resolve whether •OH was involved in the loss of adenine, ethanol or catalase were added separately to adenine/pyrite suspensions.
Negative_regulation (loss) of catalase
6) Confidence 0.43 Published 2010 Journal Geochem Trans Section Body Doc Link PMC2873965 Disease Relevance 0 Pain Relevance 0
In the group T, CAT activity decreased at all time points when compared with baseline, but the observed decrease was only statistically significant at BTR (34.70 +/- 9.27 vs. 39.69 +/- 12.91 UL-1, p < 0.05).
Negative_regulation (decreased) of CAT
7) Confidence 0.42 Published 2010 Journal Vojnosanit Pregl Section Body Doc Link 20845670 Disease Relevance 0 Pain Relevance 0
The impaired antioxidant status is shown by decreased serum levels of erythrocyte SOD [51, 90] and GSH-Px activities [51, 90, 92, 93] of increased PON1 activity [54] and of increased [90] or decreased [51] serum CAT activity in patients with psoriasis.
Negative_regulation (decreased) of CAT in erythrocyte associated with psoriasis
8) Confidence 0.42 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2914266 Disease Relevance 1.55 Pain Relevance 0.23
Assay mixture containing 0.3 mM L-Trp, 0.1 mM Fe(NH4)2(SO4)2, 1 mM 6-methyl-tetrahydropterin (6-MPH4), 2 mM NSD1015 (a inhibitor of the aromatic amino acid decarboxylase), 25 mM DTT, 2 mg/ml catalase, and 50 mM HEPES, pH 7.2 were reacted at 30°C for 20 min with shaking in the dark.
Negative_regulation (inhibitor) of catalase
9) Confidence 0.42 Published 2009 Journal Mol Brain Section Body Doc Link PMC2673217 Disease Relevance 0 Pain Relevance 0.05
Forskolin-induced CAT activity was attenuated by imipramine and fluoxetine and to a lesser degree by amitriptyline and desipramine in differentiated cells, whereas other drugs were inactive.
Negative_regulation (attenuated) of CAT associated with desipramine, endep and fluoxetine
10) Confidence 0.42 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 14735130 Disease Relevance 0.06 Pain Relevance 0.54
Catalase (CAT) activity declined (25%) with morphine dependence that was further declined by infection.
Negative_regulation (declined) of CAT associated with addiction, infection and morphine
11) Confidence 0.42 Published 2008 Journal Mol. Cell. Biochem. Section Abstract Doc Link 17934700 Disease Relevance 1.37 Pain Relevance 1.04
The increased cellular levels of catalase suppressed demyelination and blood-brain barrier disruption at the foci in the optic nerve where prior magnetic resonance imaging and histopathologic studies have demonstrated the demyelinating inflammation of experimental and human optic neuritis.
Negative_regulation (suppressed) of catalase in brain
12) Confidence 0.41 Published 1999 Journal Arch. Ophthalmol. Section Body Doc Link 10565523 Disease Relevance 0 Pain Relevance 0
The results evidenced a significant recovery in the activities of superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), glutathione reductase (GR) and glutathione (GSH) levels by antidepressant treatments following a restraint stress-induced decline of these parameters.
Negative_regulation (reductase) of CAT associated with stress and antidepressant
13) Confidence 0.41 Published 2009 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 19059298 Disease Relevance 0.59 Pain Relevance 0.47
Activity of CAT was significantly decreased in adenocarcinoma patients when compared to women with polyps or myoma.
Negative_regulation (decreased) of CAT associated with adenocarcinoma, polyps and myoma
14) Confidence 0.41 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2805669 Disease Relevance 1.70 Pain Relevance 0.16
One unit of CAT activity is defined as 1 ?
Negative_regulation (unit) of CAT
15) Confidence 0.41 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2805669 Disease Relevance 0 Pain Relevance 0
Here we present data demonstrating immediate dose-dependent generation of hydrogen peroxide in UV-irradiated melanocytes, which correlated directly with a decrease in catalase activity.
Negative_regulation (decrease) of catalase in melanocytes
16) Confidence 0.36 Published 2009 Journal Pigment Cell Melanoma Res Section Abstract Doc Link 19659742 Disease Relevance 0.25 Pain Relevance 0.21
The increased cellular levels of catalase reduced demyelination by 30%, optic nerve head swelling by 25%, cellular infiltration by 26%, disruption of the blood-brain barrier by 61%, and in vivo levels of hydrogen peroxide by 81%.
Negative_regulation (reduced) of catalase in blood
17) Confidence 0.36 Published 1999 Journal Arch. Ophthalmol. Section Body Doc Link 10565523 Disease Relevance 0 Pain Relevance 0
The distinct effect of capsaicin-induced apoptosis on the expression pattern of HepG2 proteins includes the downregulation of some antioxidant enzymes including aldose reductase (AR), catalase, enolase 1, peroxiredoxin 1, but upregulation of peroxiredoxin 6, cytochrome c oxidase, and SOD2.
Negative_regulation (downregulation) of catalase associated with qutenza and apoptosis
18) Confidence 0.35 Published 2008 Journal Proteomics Section Abstract Doc Link 18991268 Disease Relevance 0.74 Pain Relevance 0.58
RESULTS: Cytoplasmic values of manganese SOD, catalase, and glutathione peroxidase were decreased in pancreatic cells from chronic pancreatitis specimens when compared with normal pancreas.
Negative_regulation (decreased) of catalase in pancreas
19) Confidence 0.31 Published 2003 Journal Pancreas Section Body Doc Link 12499913 Disease Relevance 0 Pain Relevance 0
In ischaemic heart conditions we report a remarkable increase in platelet xanthine oxidase activity and rise in the levels of malondialdehyde (MDA) with concomitant decrease in the activities of free radical scavenging enzymes - superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase.
Negative_regulation (decrease) of catalase in platelet
20) Confidence 0.29 Published 2000 Journal Int. J. Cardiol. Section Abstract Doc Link 11121594 Disease Relevance 0.15 Pain Relevance 0.07

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