INT355364

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Context Info
Confidence 0.04
First Reported 2011
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.51
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (PTHLH, Tnfsf11) cytoplasm (PTHLH, Tnfsf11) extracellular space (PTHLH, Tnfsf11)
extracellular region (PTHLH, Tnfsf11) cell differentiation (Tnfsf11) Golgi apparatus (PTHLH)
Anatomy Link Frequency
osteoclast 2
PTHLH (Homo sapiens)
Tnfsf11 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 4 99.06 Very High Very High Very High
analgesia 2 57.12 Quite High
Spinal cord 1 55.44 Quite High
Pain 4 52.84 Quite High
antagonist 14 50.00 Quite Low
imagery 6 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 84 98.06 Very High Very High Very High
Hypercalcemia 23 95.80 Very High Very High Very High
Metastasis 45 93.32 High High
Osteoporosis 34 86.28 High High
Spontaneous Fractures 2 75.32 Quite High
Reprotox - General 1 26 68.04 Quite High
Pain 4 52.84 Quite High
Osteolysis 9 44.64 Quite Low
Multiple Myeloma 10 41.68 Quite Low
Carcinoma 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cancer cells release paradigmatic “osteolytic” cytokines, such as parathyroid hormone-related protein (PTHrP), receptor activator of NF-B ligand (RANKL), interleukin-8 (IL-8) and colony stimulating factor-1 (CSF-1), directly or indirectly responsible for the increase in osteoclast recruitment, activity and survival.
Regulation (responsible) of PTHrP Positive_regulation (activator) of RANKL in osteoclast associated with cancer and cytokine
1) Confidence 0.04 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020964 Disease Relevance 1.51 Pain Relevance 0.19

General Comments

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