INT355407

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Context Info
Confidence 0.40
First Reported 2011
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.69
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cellular_component (Crybb2)
Anatomy Link Frequency
retina 2
Crybb2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 20 87.24 High High
Kinase C 2 54.32 Quite High
gABA 2 50.80 Quite High
GABAergic 2 43.84 Quite Low
cytokine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 124 99.36 Very High Very High Very High
Ocular Hypertension 2 99.26 Very High Very High Very High
Ganglion Cysts 4 98.32 Very High Very High Very High
Stress 4 96.24 Very High Very High Very High
INFLAMMATION 20 87.24 High High
Apoptosis 10 77.32 Quite High
Shock 2 69.96 Quite High
Diabetic Retinopathy 34 67.64 Quite High
Disease 2 18.48 Low Low
Ocular Toxicity (including Many Sub-types) 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The continued induction of Cryba3 and Crybb2 after restoration of normoglycemia by insulin may be beneficial but also suggests continuing stress to the retina.
Positive_regulation (induction) of Crybb2 in retina associated with stress
1) Confidence 0.40 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020973 Disease Relevance 0.76 Pain Relevance 0.09
Beta crystallins are expressed more highly in the retina than in other non-lens tissues [34], [35], and Cryba3 was recently reported to be restricted to astrocytes in the neural retina [36] Neuroprotection of retinal ganglion cells in a rodent model of ocular hypertension has also been reported to depend on upregulation of Crybb2.
Positive_regulation (upregulation) of Crybb2 in retina associated with ganglion cysts and ocular hypertension
2) Confidence 0.40 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020973 Disease Relevance 0.93 Pain Relevance 0.04

General Comments

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