INT35548

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Context Info
Confidence 0.45
First Reported 1983
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 9
Total Number 15
Disease Relevance 10.62
Pain Relevance 2.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mme) plasma membrane (Mme)
Anatomy Link Frequency
lung 4
plasma 1
leucocyte 1
fat 1
Mme (Mus musculus)
Pain Link Frequency Relevance Heat
Endogenous opioid 3 99.58 Very High Very High Very High
headache 3 99.56 Very High Very High Very High
Enkephalin 21 99.44 Very High Very High Very High
Inflammation 65 99.36 Very High Very High Very High
withdrawal 3 98.68 Very High Very High Very High
Morphine 3 96.76 Very High Very High Very High
Physical dependence 1 96.08 Very High Very High Very High
antagonist 5 92.52 High High
Antinociceptive 1 89.88 High High
ketamine 2 88.32 High High
Disease Link Frequency Relevance Heat
Adult Respiratory Distress Syndrome 529 99.48 Very High Very High Very High
Adverse Drug Reaction 1 99.44 Very High Very High Very High
INFLAMMATION 68 99.36 Very High Very High Very High
Lung Injury 82 99.02 Very High Very High Very High
Injury 130 98.68 Very High Very High Very High
Opiate Addiction 2 98.68 Very High Very High Very High
Burns 50 98.54 Very High Very High Very High
Anxiety Disorder 2 97.78 Very High Very High Very High
Malignant Neoplastic Disease 3 96.60 Very High Very High Very High
Drug Dependence 1 96.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of the enkephalinase inhibitor phosphoramidon on the withdrawal syndrome following acute and chronic morphine-induced physical dependence in mice, was investigated.
Spec (investigated) Regulation (effect) of enkephalinase associated with physical dependence, withdrawal and morphine
1) Confidence 0.45 Published 1986 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 3539055 Disease Relevance 0.19 Pain Relevance 0.58
The effects of two enkephalinase inhibitors (thiorphan and ac├ętorphan) and DALAMIDE on gastric emptying of fat or non-fat meals were evaluated in mice.
Regulation (effects) of enkephalinase in fat
2) Confidence 0.45 Published 1988 Journal Life Sci. Section Abstract Doc Link 3164437 Disease Relevance 0 Pain Relevance 0
Influence of enkephalinase inhibitors on gastric emptying in mice depends on the nature of the meal.
Regulation (Influence) of enkephalinase
3) Confidence 0.45 Published 1988 Journal Life Sci. Section Title Doc Link 3164437 Disease Relevance 0 Pain Relevance 0.09
Double-blind study of effects of enkephalinase inhibitor on adverse reactions to myelography.
Regulation (effects) of enkephalinase associated with adverse drug reaction and headache
4) Confidence 0.45 Published 1983 Journal AJNR Am J Neuroradiol Section Title Doc Link 6224405 Disease Relevance 0.76 Pain Relevance 0.54
To study the transcriptional regulation of the NEP gene, we also measured the NEP mRNA levels in lung tissue of mice with ALI, using semi-quantitative RT-PCR.
Regulation (regulation) of NEP gene in lung associated with adult respiratory distress syndrome
5) Confidence 0.27 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 0.58 Pain Relevance 0
Selank in a dose of 100 micrograms/kg produced an anxiolytic effect in the open-field test and increased the half-life of plasma leu-enkephalin in BALB/c mice, but had no effect on behavioral reactions and enkephalinase activities in C57Bl/6 mice.
Neg (no) Regulation (effect) of enkephalinase in plasma associated with anxiety disorder and enkephalin
6) Confidence 0.24 Published 2002 Journal Bull. Exp. Biol. Med. Section Abstract Doc Link 12432865 Disease Relevance 0.26 Pain Relevance 0.44
A deeper understanding of the regulation of NEP activity in ALI/ARDS would yield valuable mechanistic information.
Regulation (regulation) of NEP associated with adult respiratory distress syndrome
7) Confidence 0.24 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 1.50 Pain Relevance 0.06
To study the transcriptional regulation of the NEP gene, we also measured the NEP mRNA levels in lung tissue of mice with ALI, using semi-quantitative RT-PCR.
Regulation (measured) of NEP in lung associated with adult respiratory distress syndrome
8) Confidence 0.24 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 0.63 Pain Relevance 0
The main objective of this study was to clarify the regulation of NEP activity and its expression during ALI/ARDS.


Regulation (regulation) of NEP associated with adult respiratory distress syndrome
9) Confidence 0.24 Published 2010 Journal Respir Res Section Abstract Doc Link PMC3009633 Disease Relevance 1.19 Pain Relevance 0.04
Thus, the objectives of this study were to 1) measure the activity of NEP in clinical and experimental lung injury, and 2) clarify the systemic and intra-alveolar regulation of NEP activity in ALI/ARDS, using a newly developed high-sensitivity measurement system.


Regulation (regulation) of NEP in lung associated with lung injury and adult respiratory distress syndrome
10) Confidence 0.24 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 1.55 Pain Relevance 0.05
Therefore, we supplemented our investigations of the regulatory mechanisms of NEP activity by adding the mice experiments.
Spec (investigations) Regulation (regulatory) of NEP
11) Confidence 0.24 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 1.32 Pain Relevance 0.07
Alterations within the endogenous opioid system in mice with targeted deletion of the neutral endopeptidase ('enkephalinase') gene.
Regulation (targeted) of neutral endopeptidase associated with endogenous opioid and enkephalin
12) Confidence 0.23 Published 2000 Journal Regul. Pept. Section Title Doc Link 11102652 Disease Relevance 0.22 Pain Relevance 0.82
CONCLUSIONS: The pharmacological effects induced by dual inhibitors acting on both NEP and APN are mainly due to the protection of the endogenous enkephalins at supraspinal and peripheral levels.
Regulation (acting) of NEP
13) Confidence 0.18 Published 2008 Journal Psychopharmacology (Berl.) Section Body Doc Link 17906961 Disease Relevance 0 Pain Relevance 0
Mechanisms of toxic smoke inhalation and burn injury: Role of neutral endopeptidase and vascular leakage in mice

The effects of neutral endopeptidase (NEP) in acute inflammation in the lung were studied using a newly developed murine model of smoke and burn (SB) injury.

Regulation (effects) of neutral endopeptidase in lung associated with inflammation, burns and injury
14) Confidence 0.08 Published 2009 Journal Toxicology Mechanisms and Methods Section Title Doc Link PMC2736052 Disease Relevance 1.66 Pain Relevance 0.14
Immunohistochemical staining was positive for leucocyte common antigen (LCA), CD10, CD20, CD79, and terminal deoxynucleotidyl transferase (TdT).
Regulation (positive) of CD10 in leucocyte
15) Confidence 0.05 Published 2009 Journal Int J Oral Maxillofac Surg Section Abstract Doc Link 19665353 Disease Relevance 0.75 Pain Relevance 0.13

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