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Context Info
Confidence 0.09
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.77
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (GGT5) plasma membrane (GGT5) transferase activity, transferring acyl groups (GGT5)
cellular amino acid metabolic process (GGT5)
Anatomy Link Frequency
Notch 1
liver 1
GGT5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory marker 1 94.44 High High
imagery 1 93.56 High High
Neurotransmitter 5 91.48 High High
Inflammation 2 87.12 High High
fibrosis 1 85.76 High High
antidepressant 73 79.44 Quite High
depression 57 78.28 Quite High
Neuritis 1 75.40 Quite High
headache 2 60.24 Quite High
Bile 3 56.20 Quite High
Disease Link Frequency Relevance Heat
Liver Disease 1 94.80 High High
INFLAMMATION 3 94.16 High High
Fatty Liver 1 93.76 High High
Increased Venous Pressure Under Development 4 86.48 High High
Fibrosis 1 85.76 High High
Neuroblastoma 1 84.28 Quite High
Biliary Liver Cirrhosis 5 82.96 Quite High
Depression 61 78.28 Quite High
Congenital Anomalies 4 77.12 Quite High
Neuritis 1 75.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of importance, fenofibrate can significantly decrease serum uric acid levels by increasing renal urate expression, and considerable reductions in serum alkaline phosphatase and gamma glutamyltransferase activity are commonly observed during therapy with fenofibrate.63,68 The latter effects may have an application in patients with liver diseases, including nonalcoholic fatty liver disease.
Negative_regulation (reductions) of gamma glutamyltransferase in liver associated with fatty liver and liver disease
1) Confidence 0.09 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922314 Disease Relevance 0.39 Pain Relevance 0.08
In fact, it was prevented by the inhibition of the proteolytic gamma-secretase enzyme or the transcription machinery, and was mimicked by the transfection of the intracellular domain of Notch.
Negative_regulation (inhibition) of proteolytic gamma-secretase enzyme in Notch
2) Confidence 0.08 Published 2009 Journal Dev Neurobiol Section Abstract Doc Link 19263417 Disease Relevance 0.45 Pain Relevance 0.17
These included a 37% decrease in mean serum alkaline phosphatase and a 43% decrease in gamma-glutamyltransferase (controls +3% and -14%, respectively).
Negative_regulation (decrease) of gamma-glutamyltransferase
3) Confidence 0.03 Published 1988 Journal Gastroenterology Section Abstract Doc Link 3169499 Disease Relevance 0.79 Pain Relevance 0.15
With this in mind, the following 7 (out of the possible 27) genes in the folate pathway will be investigated in the first instance:

• methylenetetrahydrofolate reductase • thymidylate synthase • dihydrofolate reductase • methionine synthase • methionine synthase reductase • gamma glutamyl hydrolase • reduced folate carrier (SLC19A1).

Negative_regulation (reduced) of gamma glutamyl
4) Confidence 0.03 Published 2007 Journal BMC Psychiatry Section Body Doc Link PMC2238748 Disease Relevance 0.08 Pain Relevance 0.08

General Comments

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