INT3557

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Context Info
Confidence 0.67
First Reported 1975
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 8.73
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (C1S) extracellular region (C1S)
C1S (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 24 98.60 Very High Very High Very High
Pain 13 89.56 High High
anesthesia 2 89.16 High High
cytokine 4 68.48 Quite High
Angina 1 54.84 Quite High
agonist 6 31.76 Quite Low
Bile 58 5.00 Very Low Very Low Very Low
cva 22 5.00 Very Low Very Low Very Low
metalloproteinase 18 5.00 Very Low Very Low Very Low
nud 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 542 100.00 Very High Very High Very High
Hereditary Angioedema 32 100.00 Very High Very High Very High
Coronary Artery Disease 315 98.88 Very High Very High Very High
Disease 31 98.74 Very High Very High Very High
INFLAMMATION 29 98.60 Very High Very High Very High
Cardiovascular Disease 54 98.20 Very High Very High Very High
Hypertriglyceridemia 11 95.88 Very High Very High Very High
Pressure And Volume Under Development 23 95.28 Very High Very High Very High
Increased Venous Pressure Under Development 51 94.68 High High
Pain 5 89.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Epidemiological data indicate that every 1 mg/dL increase in HDL-C is associated with a reduction in cardiac events of 2%–4%, independent of LDL-C (Gordon et al 1989).
Positive_regulation (increase) of C is associated with disorder of lipid metabolism
1) Confidence 0.67 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993967 Disease Relevance 1.32 Pain Relevance 0.05
Analysis of major randomized control trials shows that each 1% increase in HDL-C is associated with a 0.7% to 3% decrease in CHD.19–21,27,28 Thus, the risk factor associated with low HDL-C should be considered as an major independent risk factor for CHD.29
Positive_regulation (increase) of C is associated with coronary artery disease and disorder of lipid metabolism
2) Confidence 0.67 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835557 Disease Relevance 1.48 Pain Relevance 0
Elevation of C1s often was greater than elevation of C1q, displaying an independent variation of C1s and C1q in both postoperative and inflammatory disease patient groupds.
Neg (independent) Positive_regulation (variation) of C1s associated with inflammation and disease
3) Confidence 0.49 Published 1975 Journal Int. Arch. Allergy Appl. Immunol. Section Abstract Doc Link 805770 Disease Relevance 0.46 Pain Relevance 0.32
It has also been demonstrated that the risk associated with HDL-C is independent of LDL-C levels (Castelli et al 1987).
Neg (independent) Positive_regulation (independent) of C is associated with disorder of lipid metabolism
4) Confidence 0.49 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464751 Disease Relevance 0.99 Pain Relevance 0
Nevertheless, a 1% increase in HDL-C is associated with anywhere from a 0.7 to 3% decrease in CHD events.
Positive_regulation (increase) of C is associated with coronary artery disease and disorder of lipid metabolism
5) Confidence 0.45 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835557 Disease Relevance 2.08 Pain Relevance 0
According to several clinical trials, a 1% increase in HDL-C is associated with a 0.7%–3% decrease in CHD events.
Positive_regulation (increase) of C is associated with coronary artery disease and disorder of lipid metabolism
6) Confidence 0.45 Published 2010 Journal Vascular Health and Risk Management Section Abstract Doc Link PMC2835557 Disease Relevance 0.88 Pain Relevance 0
The APC/C is activated by WD repeat proteins in a cell cycle-specific manner and the activation pattern of the APC/C is remarkably conserved from yeast to human.
Positive_regulation (activated) of C is
7) Confidence 0.45 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0 Pain Relevance 0
The APC/C is activated initially by fizzy (fzy), a Drosophila homologue of p55CDC in rat and human, during the metaphase transition.
Positive_regulation (activated) of C is
8) Confidence 0.45 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.06 Pain Relevance 0
The disease results from mutations in the C1 esterase inhibitor gene that cause C1 esterase inhibitor deficiency.
Positive_regulation (cause) of C1 esterase associated with hereditary angioedema and disease
9) Confidence 0.31 Published 2010 Journal J Cardiothorac Surg Section Abstract Doc Link PMC2965712 Disease Relevance 1.12 Pain Relevance 0.09
In line with upregulation of C1S, downregulation of one of its inhibitors, SERPINE2, was observed.
Positive_regulation (upregulation) of C1S
10) Confidence 0.15 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2519092 Disease Relevance 0.26 Pain Relevance 0.07

General Comments

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