INT355719

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Context Info
Confidence 0.49
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.67
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Krt27) cytoplasm (Krt27)
Anatomy Link Frequency
hippocampus 1
Krt27 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 20 98.92 Very High Very High Very High
ischemia 1 47.04 Quite Low
long-term potentiation 3 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
amygdala 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 64 96.88 Very High Very High Very High
Coma 1 47.96 Quite Low
Cv Unclassified Under Development 1 47.04 Quite Low
Convulsion 4 46.64 Quite Low
Status Epilepticus 1 44.16 Quite Low
Anxiety Disorder 24 5.00 Very Low Very Low Very Low
Post-traumatic Stress Disorder 9 5.00 Very Low Very Low Very Low
Mental Disorders 4 5.00 Very Low Very Low Very Low
Depression 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic social defeat stress has been shown to downregulate the mRNA levels of BDNF transcripts IV and VI in the mouse hippocampus, which is accompanied by significant increases in H3-K27 dimethylation at the promoter of exons IV and VI without changes in H3 acetylation status at the promoter of either exons IV or VI.7 This result taken together with our findings suggests that chromatin remodeling through histone modification could play an important role in stress-induced gene expression in vivo.
Positive_regulation (dimethylation) of K27 in hippocampus associated with stress and hippocampus
1) Confidence 0.49 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 0.67 Pain Relevance 0.23

General Comments

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