INT355722

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.57
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cellular_component (Hist2h4) biological_process (Hist2h4)
Anatomy Link Frequency
hippocampus 1
Hist2h4 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 20 94.80 High High
ischemia 1 10.80 Low Low
long-term potentiation 3 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
amygdala 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Status Epilepticus 1 96.54 Very High Very High Very High
Convulsion 4 90.08 High High
Stress 64 83.72 Quite High
Coma 1 11.72 Low Low
Cv Unclassified Under Development 1 10.80 Low Low
Anxiety Disorder 24 5.00 Very Low Very Low Very Low
Post-traumatic Stress Disorder 9 5.00 Very Low Very Low Very Low
Mental Disorders 4 5.00 Very Low Very Low Very Low
Depression 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To our knowledge, only 2 studies have examined the regulatory effect of histone acetylation on the expression of BDNF mRNA in the rat hippocampus after an acute stimulation.15,20 In response to pilocarpine-induced status epilepticus, increased levels of exon I and IV of the BDNF gene were, at least in part, derived from the hyperacetylation of histone H4 at the P2 promoter and deacetylation of histone H4 associated with the P4 promoter.20 Likewise, the marked increase in histone H4 acetylation, but not histone H3 acetylation, at the P2 promoter of the BDNF gene correlated with an increase in total BDNF mRNA in the rat hippocampus 2 h after electroconvulsive seizure.15 In contrast with our study, these previous studies indicated the importance of histone H4 acetylation at the P2 promoter in the regulation of BDNF mRNA expression.
H4 Binding (associated) of in hippocampus associated with convulsion, status epilepticus and hippocampus
1) Confidence 0.01 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 0.57 Pain Relevance 0.18

General Comments

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