INT355722

Context Info Confidence 0.01 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.57 Pain Relevance 0.18

cellular_component (Hist2h4) biological_process (Hist2h4)

Anatomy Link Frequency hippocampus 1 Hist2h4 (Mus musculus)

Pain Link Frequency Relevance Heat Hippocampus 20 94.80 ischemia 1 10.80 long-term potentiation 3 5.00 depression 2 5.00 anesthesia 1 5.00 amygdala 1 5.00

Disease Link Frequency Relevance Heat Status Epilepticus 1 96.54 Convulsion 4 90.08 Stress 64 83.72 Coma 1 11.72 Cv Unclassified Under Development 1 10.80 Anxiety Disorder 24 5.00 Post-traumatic Stress Disorder 9 5.00 Mental Disorders 4 5.00 Depression 2 5.00 Injury 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

To our knowledge, only 2 studies have examined the regulatory effect of histone acetylation on the expression of BDNF mRNA in the rat hippocampus after an acute stimulation.15,20 In response to pilocarpine-induced status epilepticus, increased levels of exon I and IV of the BDNF gene were, at least in part, derived from the hyperacetylation of histone H4 at the P2 promoter and deacetylation of histone H4 associated with the P4 promoter.20 Likewise, the marked increase in histone H4 acetylation, but not histone H3 acetylation, at the P2 promoter of the BDNF gene correlated with an increase in total BDNF mRNA in the rat hippocampus 2 h after electroconvulsive seizure.15 In contrast with our study, these previous studies indicated the importance of histone H4 acetylation at the P2 promoter in the regulation of BDNF mRNA expression.

H4 Binding (associated) of in hippocampus associated with convulsion, status epilepticus and hippocampus

1) Confidence 0.01 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 0.57 Pain Relevance 0.18

General Comments

This test has worked.