INT355723

Context Info Confidence 0.02 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.72 Pain Relevance 0.08

cellular_component (Hist2h4) biological_process (Hist2h4)

Hist2h4 (Mus musculus)

Pain Link Frequency Relevance Heat Hippocampus 20 87.04 long-term potentiation 3 5.00 depression 2 5.00 anesthesia 1 5.00 ischemia 1 5.00 amygdala 1 5.00

Disease Link Frequency Relevance Heat Stress 64 97.64 Anxiety Disorder 24 97.20 Post-traumatic Stress Disorder 9 5.00 Convulsion 4 5.00 Mental Disorders 4 5.00 Depression 2 5.00 Injury 2 5.00 Coma 1 5.00 Decapitation 1 5.00 Cv Unclassified Under Development 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The results of the fear conditioning study showed that footshock stress significantly increased the levels of total, exon I, and exon IV BDNF mRNA, with significantly increased acetylation levels of both histone H3 and H4, at the promoter of exons I and IV, followed by enhanced freezing to fear-context exposure.

Transcription (levels) of H4 associated with stress and anxiety disorder

1) Confidence 0.02 Published 2010 Journal Psychiatry Investigation Section Abstract Doc Link PMC3022311 Disease Relevance 0.72 Pain Relevance 0.08

General Comments

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