INT355732

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Context Info
Confidence 0.13
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.87
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pdgfb, Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf) cytoplasm (Pdgfb)
Anatomy Link Frequency
hippocampus 1
Pdgfb (Rattus norvegicus)
Bdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 20 98.20 Very High Very High Very High
ischemia 1 97.92 Very High Very High Very High
long-term potentiation 3 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
amygdala 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 64 100.00 Very High Very High Very High
Coma 1 98.38 Very High Very High Very High
Cv Unclassified Under Development 1 97.92 Very High Very High Very High
Convulsion 4 97.72 Very High Very High Very High
Mental Disorders 4 23.60 Low Low
Anxiety Disorder 24 5.00 Very Low Very Low Very Low
Post-traumatic Stress Disorder 9 5.00 Very Low Very Low Very Low
Depression 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low
Decapitation 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Differential usage of multiple promoters of BDNF is considered to generate region-specific expression and responses to both physiological stimuli such as diurnal rhythm and exercise, and pathophysiological insults such as seizures, ischemia, and hypoglycemic coma.16-18 Recently, Nair et al.,19 using in situ hybridization, demonstrated that a SIS significantly decreased the levels of all exon-specific BDNF mRNAs in the dentate gyrus of the adult rat hippocampus.
SIS Negative_regulation (decreased) of BDNF in hippocampus associated with stress, convulsion, ischemia, hippocampus and coma
1) Confidence 0.13 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 0.87 Pain Relevance 0.17

General Comments

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