INT355765

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Context Info
Confidence 0.10
First Reported 2011
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.75
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Hmgb1) cell morphogenesis (Hmgb1) nucleolus (Hmgb1)
chromosome (Hmgb1) nucleus (Hmgb1) transcription factor binding (Hmgb1)
Anatomy Link Frequency
immune system 2
Hmgb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 6 100.00 Very High Very High Very High
cytokine 1 100.00 Very High Very High Very High
rheumatoid arthritis 31 81.44 Quite High
Arthritis 5 22.64 Low Low
visual analogue scale 4 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
Rheumatism 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 7 100.00 Very High Very High Very High
Cancer 2 100.00 Very High Very High Very High
Necrosis 1 100.00 Very High Very High Very High
Disease 21 95.84 Very High Very High Very High
Rheumatoid Arthritis 31 81.44 Quite High
General Immunology 1 67.48 Quite High
Autoimmune Hemolytic Anemia 1 36.16 Quite Low
Thyroiditis 1 34.36 Quite Low
Autoimmune Disease 2 32.20 Quite Low
Uveitis 1 23.44 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, excess amounts of bacteria toxins absorbed from the GI mucosa may directly stimulate the release of pro-inflammatory cytokines such as tumour necrosis factor (TNF), interleukin-1 (IL-1) [26], and high mobility group box-1 (HMGB1) protein [27], which could exacerbate inflammatory reactions [23,28,29], but also systemically affect the host's immune system for prolonged periods as non-specific immunostimulants.
Spec (may) Positive_regulation (stimulate) of Localization (release) of high mobility group box-1 in immune system associated with necrosis, inflammation, cancer and cytokine
1) Confidence 0.10 Published 2011 Journal Nutr J Section Body Doc Link PMC3022554 Disease Relevance 0.75 Pain Relevance 0.24

General Comments

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