INT355815

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Context Info
Confidence 0.32
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.26
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (NAV1) endosome (BACE1) peptidase activity (BACE1)
Golgi apparatus (BACE1) endoplasmic reticulum (BACE1) enzyme binding (BACE1)
Anatomy Link Frequency
neuronal 2
BACE1 (Homo sapiens)
NAV1 (Homo sapiens)
Pain Link Frequency Relevance Heat
sodium channel 99 100.00 Very High Very High Very High
Nav1.1 4 92.80 High High
imagery 2 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 1 95.00 High High
Neuroblastoma 3 90.00 High High
Adhesions 1 74.48 Quite High
Disease 4 25.48 Quite Low
Alzheimer's Dementia 4 21.32 Low Low
Stress 3 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 1 5.00 Very Low Very Low Very Low
Injury 1 5.00 Very Low Very Low Very Low
Disease Progression 1 5.00 Very Low Very Low Very Low
Brain Injury 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data strongly suggest that BACE1 can regulate neuronal function, possibly by cleaving Nav?
BACE1 Regulation (regulate) of Positive_regulation (cleaving) of Nav in neuronal associated with sodium channel
1) Confidence 0.32 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3022600 Disease Relevance 0.26 Pain Relevance 0.72

General Comments

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