INT355819

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Context Info
Confidence 0.71
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 1.21
Pain Relevance 4.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (NAV1) cytoplasm (NAV1)
Anatomy Link Frequency
cleavage 7
NAV1 (Homo sapiens)
Pain Link Frequency Relevance Heat
sodium channel 693 100.00 Very High Very High Very High
Nav1.1 28 96.80 Very High Very High Very High
ischemia 7 58.80 Quite High
imagery 14 51.84 Quite High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 28 97.68 Very High Very High Very High
Neuroblastoma 21 94.16 High High
Adhesions 7 88.52 High High
Targeted Disruption 7 87.40 High High
Stress 21 79.12 Quite High
Disease 28 69.68 Quite High
Cv Unclassified Under Development 7 58.80 Quite High
Brain Injury 7 58.08 Quite High
Injury 7 56.72 Quite High
Disease Progression 7 54.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To specifically measure BACE1-mediated cleavage of Nav?
Protein_catabolism (cleavage) of Nav in cleavage associated with sodium channel
1) Confidence 0.71 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3022600 Disease Relevance 0 Pain Relevance 0.40
-secretase cleavage of Nav?
Protein_catabolism (cleavage) of Nav in cleavage associated with sodium channel
2) Confidence 0.63 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3022600 Disease Relevance 0 Pain Relevance 0.62
2-ICD (intracellular domain) through cleavage of Nav?
Protein_catabolism (cleavage) of Nav in cleavage associated with sodium channel
3) Confidence 0.63 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3022600 Disease Relevance 0.27 Pain Relevance 0.65
In order to better understand the role of BACE1 in Nav metabolism, we have identified the BACE1 cleavage site in human Nav?
Protein_catabolism (cleavage) of Nav in cleavage associated with sodium channel
4) Confidence 0.55 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3022600 Disease Relevance 0.24 Pain Relevance 0.74
M) is mainly responsible for BACE1 cleavage of human Nav?
Protein_catabolism (cleavage) of Nav in cleavage associated with sodium channel
5) Confidence 0.47 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3022600 Disease Relevance 0.71 Pain Relevance 0.59
In our previous studies, we have found that elevated BACE1-mediated cleavage of human Nav?
Protein_catabolism (cleavage) of Nav in cleavage associated with sodium channel
6) Confidence 0.47 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3022600 Disease Relevance 0 Pain Relevance 0.60
However, the cleavage of Nav?
Protein_catabolism (cleavage) of Nav in cleavage associated with sodium channel
7) Confidence 0.47 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3022600 Disease Relevance 0 Pain Relevance 0.60

General Comments

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