INT35584

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Context Info
Confidence 0.35
First Reported 1988
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 22
Total Number 24
Disease Relevance 31.78
Pain Relevance 7.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ACLY) mitochondrion (ACLY) small molecule metabolic process (ACLY)
nucleolus (ACLY) plasma membrane (ACLY) nucleus (ACLY)
Anatomy Link Frequency
knee 2
venous sinus 2
plasma 1
Anterior 1
brains 1
ACLY (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 500 100.00 Very High Very High Very High
headache 141 99.44 Very High Very High Very High
Migraine 99 99.36 Very High Very High Very High
Perioperative pain 1 99.28 Very High Very High Very High
Multiple sclerosis 368 97.24 Very High Very High Very High
Inflammation 101 96.68 Very High Very High Very High
analgesia 1 93.80 High High
alcohol 14 93.36 High High
imagery 203 92.40 High High
anesthesia 20 92.32 High High
Disease Link Frequency Relevance Heat
Deafness 126 100.00 Very High Very High Very High
Pseudotumor Cerebri 126 100.00 Very High Very High Very High
Immunization 28 100.00 Very High Very High Very High
Cicatrix 12 100.00 Very High Very High Very High
Thrombosis 306 99.98 Very High Very High Very High
Transverse Myelitis 140 99.92 Very High Very High Very High
Systemic Lupus Erythematosus 841 99.84 Very High Very High Very High
Epilepsy 154 99.76 Very High Very High Very High
Headache Disorders 14 99.76 Very High Very High Very High
Cirrhosis 56 99.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IgM aCL were associated with recurrent spontaneous abortion (p less than 0.05), thrombocytopenia (p less than 0.05) as well as a positive VDRL and prolonged PTT.
aCL Binding (associated) of associated with reprotox - general 3 and thrombocytopenia
1) Confidence 0.35 Published 1988 Journal J. Rheumatol. Section Abstract Doc Link 3172093 Disease Relevance 0.62 Pain Relevance 0.08
Anterior cruciate ligament (ACL) procedures are associated with significant postoperative pain and have traditionally been done on a short-stay hospitalization basis because of concerns for adequate postoperative analgesia.
ACL Binding (associated) of in Anterior associated with perioperative pain and analgesia
2) Confidence 0.35 Published 2000 Journal Am J. Orthop. Section Abstract Doc Link 11140353 Disease Relevance 0.10 Pain Relevance 0.75
In the human knee, the ACL can be represented by two bundles: the anteromedial (AM) and the posterolateral (PL) bundle.
ACL Binding (represented) of in knee
3) Confidence 0.31 Published 2009 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2695438 Disease Relevance 0.28 Pain Relevance 0.12
The ACL was clearly impinging within the notch and appeared to restrict the range of motion.
ACL Spec (appeared) Binding (impinging) of in ACL
4) Confidence 0.18 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2412893 Disease Relevance 0.27 Pain Relevance 0.28
Regarding the first concept, it is important to point out that our assay of aPC, aPS, aPE and aCL does not identify the specific plasma antigen responsible for a positive test.
aCL Binding (assay) of in plasma
5) Confidence 0.15 Published 2007 Journal BMC Neurol Section Body Doc Link PMC2219992 Disease Relevance 0.95 Pain Relevance 0.40
After ACL repair, most patients rarely recognize slightly weakened anterior knee stability in everyday life.
ACL Binding (recognize) of in knee
6) Confidence 0.15 Published 2005 Journal BMC Surg Section Body Doc Link PMC552311 Disease Relevance 0.13 Pain Relevance 0
Commercial kits for assay of aCL and ?
aCL Binding (assay) of
7) Confidence 0.13 Published 2007 Journal BMC Neurol Section Body Doc Link PMC2219992 Disease Relevance 0.11 Pain Relevance 0.05
Budd-Chiari syndrome was first observed in APS in 198470; since then, more cases with obstruction of the large hepatic veins resulting in hepatic congestion and liver cell necrosis in APS have been reported.71 An association of portal hypertension (possibly due to thromboembolism/cirrhosis) with aPLs has been found,72,73 as well as a correlation with pulmonary hypertension.72 Thus, it has been suggested74 that a thromboembolism associated with aCL antibodies might be the underlying pathological mechanism in both conditions.
aCL Binding (associated) of in hepatic veins associated with budd-chiari syndrome, pressure and volume under development, necrosis, cirrhosis, hypertension, anti-phospholipid antibody syndrome and cva
8) Confidence 0.09 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628175 Disease Relevance 2.09 Pain Relevance 0.24
Idiopathic intracranial hypertension is frequently associated with aCL and can be the only presenting symptom of APS.
aCL Binding (associated) of associated with anti-phospholipid antibody syndrome, cva and pseudotumor cerebri
9) Confidence 0.09 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628175 Disease Relevance 1.65 Pain Relevance 0.54
A retrospective study199 confirmed the association between idiopathic intracranial hypertension and aCL, although they also found a lower frequency of aCL in their patients.
aCL Binding (association) of associated with cva and pseudotumor cerebri
10) Confidence 0.08 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628175 Disease Relevance 1.44 Pain Relevance 0.34
The authors postulated the association of sudden profound sensori-neural hearing loss with aCL in patients with autoimmune diseases.
aCL Spec (postulated) Binding (association) of in neural associated with deafness and autoimmune disease
11) Confidence 0.08 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628175 Disease Relevance 1.54 Pain Relevance 0.13
The aCL-brain phospholipid interaction in SLE may be expressed through a direct reversible mechanism by which aPLs lower the seizure threshold.162 It was also reported that aPLs might bind directly to the ependyma and myelin in the brains of animals.163


aCL Binding (interaction) of in brains associated with convulsion and systemic lupus erythematosus
12) Confidence 0.08 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628175 Disease Relevance 2.34 Pain Relevance 0.07
Another report190 described a patient with refractory hiccups as the heralding symptom of transverse myelitis in association with aCL.
aCL Binding (association) of associated with myoclonus and transverse myelitis
13) Confidence 0.08 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628175 Disease Relevance 2.09 Pain Relevance 0.42
Notably, aPLs, especially IgG aCL, is associated with chronic headache in SLE patients, but not with a particular subtype of headache or with migraines.150 For instance, both the aforementioned cerebral venous sinus thromboses and the dural ones have a diverse spectrum of clinical manifestations, the most common being headache accompanied by papilledema, nausea, vomiting, and visual field loss.
aCL Binding (especially) of in venous sinus associated with headache disorders, intracranial sinus thrombosis, papilledema, vomiting, migraine disorders, headache and systemic lupus erythematosus
14) Confidence 0.07 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628175 Disease Relevance 2.45 Pain Relevance 1.09
Autoantibodies to oxidized LDL appear in association with aCL, and it is possible that a cross-reaction of aCL with oxidized LDL could take place.
aCL Binding (association) of
15) Confidence 0.07 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628175 Disease Relevance 0.55 Pain Relevance 0.04
In a later study126 this was confirmed, and the subsequent thrombo-occlusive events were associated with IgG aCL (most frequently in patients with aCL ?
aCL Binding (associated) of
16) Confidence 0.07 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628175 Disease Relevance 0.82 Pain Relevance 0.05
However, the results are controversial; demonstrating a true association between aCL positivity and migraine is difficult since (i) there is a high frequency of migraine in normal individuals and (ii) a relatively low frequency of aCL in healthy populations. aPLs were also observed in transient neurological symptoms, including migraine with aura.
aCL Binding (association) of associated with migraine
17) Confidence 0.07 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628175 Disease Relevance 2.10 Pain Relevance 0.88
Notably, aPLs, especially IgG aCL, is associated with chronic headache in SLE patients, but not with a particular subtype of headache or with migraines.150 For instance, both the aforementioned cerebral venous sinus thromboses and the dural ones have a diverse spectrum of clinical manifestations, the most common being headache accompanied by papilledema, nausea, vomiting, and visual field loss.
aCL Binding (associated) of in venous sinus associated with headache disorders, intracranial sinus thrombosis, papilledema, vomiting, migraine disorders, headache and systemic lupus erythematosus
18) Confidence 0.07 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628175 Disease Relevance 2.45 Pain Relevance 1.09
Another study198 found aCL in six out of 14 patients (43%) with idiopathic intracranial hypertension.
aCL Binding (found) of associated with cva and pseudotumor cerebri
19) Confidence 0.06 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628175 Disease Relevance 1.34 Pain Relevance 0.39
The aPLs involvement in thrombosis is well evidenced, e.g., APS was induced after immunization with aCL or ?
aCL Binding (immunization) of associated with immunization, anti-phospholipid antibody syndrome and thrombosis related under development
20) Confidence 0.06 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628175 Disease Relevance 1.84 Pain Relevance 0.09

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