INT355843

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Context Info
Confidence 0.45
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.01
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (SETBP1) DNA binding (SETBP1)
Anatomy Link Frequency
T-cell 4
leukocyte 2
lymphocytes 2
SETBP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 44 100.00 Very High Very High Very High
antagonist 4 80.48 Quite High
Potency 24 71.80 Quite High
abdominal pain 4 33.40 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 4 98.92 Very High Very High Very High
Staphylococcus Infection 12 98.42 Very High Very High Very High
Death 20 92.76 High High
Toxicity 32 91.80 High High
Disease 8 47.40 Quite Low
Communicable Diseases 8 45.96 Quite Low
Hypersensitivity 4 45.00 Quite Low
Respiratory Failure 4 39.72 Quite Low
Heart Rate Under Development 4 38.76 Quite Low
Diarrhoea 4 33.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In an LPS-independent mouse model of airway exposure (a route thought to be relevant for mass delivery of SEB in the human population), transgenic mice bearing the human leukocyte antigen-DQ8 died as late as 6 days after 15 ?
Positive_regulation (delivery) of Gene_expression (delivery) of SEB in leukocyte associated with targeted disruption
1) Confidence 0.45 Published 2010 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC3022601 Disease Relevance 0.58 Pain Relevance 0.04
Other notable studies have included a murine toxic shock syndrome toxin 1 (TSST-1)-specific monoclonal antibody (MAb) which crossreacted to SEB by ELISA and partially inhibited SEB-induced T-cell mitogenesis as well as TNF?
Positive_regulation (by) of Gene_expression (mitogenesis) of SEB-induced in T-cell associated with staphylococcus infection
2) Confidence 0.45 Published 2010 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC3022601 Disease Relevance 0.18 Pain Relevance 0.04
Other notable studies have included a murine toxic shock syndrome toxin 1 (TSST-1)-specific monoclonal antibody (MAb) which crossreacted to SEB by ELISA and partially inhibited SEB-induced T-cell mitogenesis as well as TNF?
Positive_regulation (as) of Gene_expression (mitogenesis) of SEB-induced in T-cell associated with staphylococcus infection
3) Confidence 0.45 Published 2010 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC3022601 Disease Relevance 0.18 Pain Relevance 0.04
HuMAbs neutralize SEB-induced cytokine production by human lymphocytes
Positive_regulation (neutralize) of Gene_expression (production) of SEB-induced in lymphocytes associated with cytokine
4) Confidence 0.39 Published 2010 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC3022601 Disease Relevance 0.07 Pain Relevance 0.22

General Comments

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