INT355851

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Context Info
Confidence 0.52
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.50
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (SETBP1) DNA binding (SETBP1)
Anatomy Link Frequency
immune system 1
SETBP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 3 88.28 High High
cytokine 33 78.64 Quite High
Potency 18 60.08 Quite High
abdominal pain 3 41.20 Quite Low
Disease Link Frequency Relevance Heat
Toxicity 24 99.60 Very High Very High Very High
Staphylococcus Infection 9 93.28 High High
Disease 6 55.20 Quite High
Communicable Diseases 6 53.76 Quite High
Hypersensitivity 3 52.80 Quite High
Respiratory Failure 3 47.52 Quite Low
Heart Rate Under Development 3 46.56 Quite Low
Death 15 42.56 Quite Low
Diarrhoea 3 41.76 Quite Low
Abdominal Pain 3 41.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The use of mouse monoclonal anti-SEB antibodies to study important epitope determinants essential for MHC/TCR binding has led others to explore the use of anti-SEB antibodies for blocking SEB from engaging the immune system [15].
Negative_regulation (blocking) of SEB in immune system
1) Confidence 0.52 Published 2010 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC3022601 Disease Relevance 0.32 Pain Relevance 0.04
These HuMAbs were screened for specificity, affinity and the ability to block SEB activity in vitro as well as its lethal effect in vivo.


Negative_regulation (block) of SEB
2) Confidence 0.39 Published 2010 Journal J Immune Based Ther Vaccines Section Abstract Doc Link PMC3022601 Disease Relevance 0 Pain Relevance 0.10
Also, LeClaire et al demonstrated the feasibility of using a passive immunity strategy utilizing SEB-specific MAbs raised in chicken to block SEB-mediated toxicity in Rhesus monkeys [17].
Negative_regulation (block) of SEB associated with toxicity
3) Confidence 0.38 Published 2010 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC3022601 Disease Relevance 0.19 Pain Relevance 0.06

General Comments

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