INT35587

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Context Info
Confidence 0.03
First Reported 1988
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.34
Pain Relevance 1.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Atrn) extracellular space (Atrn) extracellular region (Atrn)
plasma membrane (Atrn) molecular_function (Atrn) cytoplasm (Atrn)
Anatomy Link Frequency
basement membrane 2
Atrn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 4 100.00 Very High Very High Very High
ischemia 106 99.52 Very High Very High Very High
metalloproteinase 40 98.16 Very High Very High Very High
Inflammation 30 93.36 High High
dorsal root ganglion 34 88.08 High High
chemokine 8 84.60 Quite High
cytokine 12 84.00 Quite High
nMDA receptor 2 76.56 Quite High
cerebral cortex 16 5.00 Very Low Very Low Very Low
Hippocampus 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cerebral Infarction 10 99.52 Very High Very High Very High
Injury 84 97.20 Very High Very High Very High
INFLAMMATION 35 93.36 High High
Ganglion Cysts 35 88.08 High High
Infarction 6 81.24 Quite High
Cv Unclassified Under Development 100 80.48 Quite High
Stress 2 75.56 Quite High
Cognitive Disorder 2 73.08 Quite High
Hypoxia 18 52.04 Quite High
Brain Injury 4 50.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The major cytosolic and membrane-associated enkephalin-degrading aminopeptidases were purified in parallel by column chromatography successively on DEAE-cellulose, AH-Sepharose, hydroxylapatite, Sephadex G-200, Affigel Blue, AH-Sepharose, and hydroxylapatite.
Protein_catabolism (degrading) of membrane associated with enkephalin
1) Confidence 0.03 Published 1988 Journal J. Neurosci. Res. Section Abstract Doc Link 3172279 Disease Relevance 0 Pain Relevance 0.17
The in-solution digestion in shotgun proteomics provides advantages for overcoming the limitations of gel separation of hydrophobic membrane proteins and permitting of adding a certain concentration of detergents or organic solvents to improve the denaturation, dissolution and proteolysis of membrane proteins.
Protein_catabolism (proteolysis) of membrane
2) Confidence 0.02 Published 2009 Journal Proteome Sci Section Body Doc Link PMC2780401 Disease Relevance 0.39 Pain Relevance 0.20
Several MMPs, particularly the gelatinases, are elevated after cerebral ischemia and have been shown to degrade basement membrane proteins [19,20].
Protein_catabolism (degrade) of membrane in basement membrane associated with ischemia, metalloproteinase and cerebral infarction
3) Confidence 0.01 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2527306 Disease Relevance 0.69 Pain Relevance 0.43
The release of proteases from activated glia results in proteolytic degradation of basement membrane constituents.
Protein_catabolism (degradation) of membrane in basement membrane
4) Confidence 0.01 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2527306 Disease Relevance 1.26 Pain Relevance 0.40

General Comments

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