INT355888

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Context Info
Confidence 0.58
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 0.87
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpm7) plasma membrane (Trpm7) kinase activity (Trpm7)
transmembrane transport (Trpm7) cytoplasm (Trpm7)
Anatomy Link Frequency
neurons 2
pyramidal neurons 1
Trpm7 (Mus musculus)
Pain Link Frequency Relevance Heat
Pyramidal cell 27 97.32 Very High Very High Very High
ischemia 45 95.32 Very High Very High Very High
Pain 9 87.32 High High
Potency 36 84.56 Quite High
Action potential 9 79.36 Quite High
Inflammation 9 77.92 Quite High
imagery 54 72.80 Quite High
antagonist 27 5.00 Very Low Very Low Very Low
tetrodotoxin 9 5.00 Very Low Very Low Very Low
Central nervous system 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Brain Hemorrhage 18 95.32 Very High Very High Very High
Epilepsy 27 94.56 High High
Pain 9 87.32 High High
INFLAMMATION 9 77.92 Quite High
Cv Unclassified Under Development 27 73.08 Quite High
Death 18 27.20 Quite Low
Stress 9 19.96 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In cultured hippocampal neurons we demonstrated that NM, and related compounds, cause a strong membrane potential-dependent inhibition of TRPM7 currents as well as an inhibition the excitatory responses evoked by lowering extracellular concentrations of divalent cations.
Negative_regulation (inhibition) of TRPM7 in neurons
1) Confidence 0.58 Published 2010 Journal Mol Brain Section Body Doc Link PMC3022637 Disease Relevance 0.11 Pain Relevance 0.15
We also found that NM inhibited TRPM7 currents expressed in HEK293T cells in direct inverse relationship to the extracellular concentrations of Ca2+ and Mg2+.
Negative_regulation (inhibited) of TRPM7
2) Confidence 0.43 Published 2010 Journal Mol Brain Section Body Doc Link PMC3022637 Disease Relevance 0.17 Pain Relevance 0.13
As TRPM7 currents are blocked by extracellular Ca2+ and Mg2+, we hypothesized that dicationic chemicals could mimic the effects of divalent cations in blocking TRPM7 channels.
Negative_regulation (blocked) of TRPM7
3) Confidence 0.42 Published 2010 Journal Mol Brain Section Body Doc Link PMC3022637 Disease Relevance 0.13 Pain Relevance 0.07
In the absence of extracellular divalent cations, NM caused a potent and voltage-dependent inhibition of TRPM7 currents which mimicked the effects of the divalent cations themselves.
Negative_regulation (inhibition) of TRPM7
4) Confidence 0.42 Published 2010 Journal Mol Brain Section Body Doc Link PMC3022637 Disease Relevance 0.15 Pain Relevance 0.11
We therefore tested if NM, by blocking TRPM7 currents, could affect neuron excitation upon reducing Ca2+.
Negative_regulation (blocking) of TRPM7 in neuron
5) Confidence 0.42 Published 2010 Journal Mol Brain Section Body Doc Link PMC3022637 Disease Relevance 0 Pain Relevance 0.07
In previous publications we showed that these currents are at least mediated in large part, if not entirely by TRPM7 channels, as they are negatively correlated with a selective knockdown of TRPM7 protein and messager both in cultured hippocampal and in vivo CA1 pyramidal neurons [5-7].
Negative_regulation (knockdown) of TRPM7 in pyramidal neurons associated with pyramidal cell
6) Confidence 0.42 Published 2010 Journal Mol Brain Section Body Doc Link PMC3022637 Disease Relevance 0 Pain Relevance 0.09
As TRPM7 currents are blocked by extracellular Ca2+ and Mg2+, we hypothesized that dicationic chemicals could mimic the effects of divalent cations in blocking TRPM7 channels.
Negative_regulation (blocking) of TRPM7
7) Confidence 0.42 Published 2010 Journal Mol Brain Section Body Doc Link PMC3022637 Disease Relevance 0.12 Pain Relevance 0.06
The effect of NM on the block of TRPM7 currents was examined on the inhibition of these currents by extracellular divalent cations (10 nM versus 0.1 mM) (Figure 6A &6B).
Negative_regulation (block) of TRPM7
8) Confidence 0.42 Published 2010 Journal Mol Brain Section Body Doc Link PMC3022637 Disease Relevance 0 Pain Relevance 0.08
Here we report that a synthetic serine protease inhibitor, nafamostat mesylate (NM), and several of its analogues, block recombinant TRPM7 currents expressed in HEK293T cells in inverse relationship to the concentration of extracellular divalent cations.
Negative_regulation (block) of recombinant TRPM7
9) Confidence 0.37 Published 2010 Journal Mol Brain Section Abstract Doc Link PMC3022637 Disease Relevance 0.19 Pain Relevance 0.05

General Comments

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