INT355892

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Context Info
Confidence 0.51
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 0.66
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpm7) plasma membrane (Trpm7) kinase activity (Trpm7)
transmembrane transport (Trpm7) cytoplasm (Trpm7)
Anatomy Link Frequency
neurons 6
Trpm7 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 35 95.52 Very High Very High Very High
Potency 28 91.44 High High
Pain 7 87.32 High High
Inflammation 7 77.92 Quite High
Pyramidal cell 21 66.00 Quite High
imagery 42 55.68 Quite High
antagonist 21 31.00 Quite Low
Central nervous system 7 22.20 Low Low
tetrodotoxin 7 5.00 Very Low Very Low Very Low
halothane 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 21 95.52 Very High Very High Very High
Brain Hemorrhage 14 95.32 Very High Very High Very High
Epilepsy 21 94.56 High High
Pain 7 87.32 High High
INFLAMMATION 7 77.92 Quite High
Death 14 59.84 Quite High
Stress 7 52.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we report that a synthetic serine protease inhibitor, nafamostat mesylate (NM), and several of its analogues, block recombinant TRPM7 currents expressed in HEK293T cells in inverse relationship to the concentration of extracellular divalent cations.
Negative_regulation (block) of Gene_expression (expressed) of recombinant TRPM7
1) Confidence 0.51 Published 2010 Journal Mol Brain Section Abstract Doc Link PMC3022637 Disease Relevance 0.19 Pain Relevance 0.05
We also found that NM inhibited TRPM7 currents expressed in HEK293T cells in direct inverse relationship to the extracellular concentrations of Ca2+ and Mg2+.
Negative_regulation (inhibited) of Gene_expression (expressed) of TRPM7
2) Confidence 0.43 Published 2010 Journal Mol Brain Section Body Doc Link PMC3022637 Disease Relevance 0.17 Pain Relevance 0.13
DAPI completely and reversibly blocked TRPM7 current with an IC50 of 38 ?
Negative_regulation (blocked) of Gene_expression (current) of TRPM7
3) Confidence 0.42 Published 2010 Journal Mol Brain Section Body Doc Link PMC3022637 Disease Relevance 0 Pain Relevance 0.03
M) inhibits TRPM7 current and pre-exposed HSB (200 ?
Negative_regulation (inhibits) of Gene_expression (current) of TRPM7
4) Confidence 0.42 Published 2010 Journal Mol Brain Section Body Doc Link PMC3022637 Disease Relevance 0 Pain Relevance 0
We were able to use this approach to show that reducing TRPM7 currents in CA1 neurons of the rat provides substantial protection against the loss of CA1 neurons in a model of global ischemia [5,7].
Negative_regulation (reducing) of Gene_expression (currents) of TRPM7 in neurons associated with ischemia
5) Confidence 0.42 Published 2010 Journal Mol Brain Section Body Doc Link PMC3022637 Disease Relevance 0.30 Pain Relevance 0.13
NM blocks TRPM7 currents in cultured Hippocampal Neurons
Negative_regulation (blocks) of Gene_expression (currents) of TRPM7 in Neurons
6) Confidence 0.37 Published 2010 Journal Mol Brain Section Body Doc Link PMC3022637 Disease Relevance 0 Pain Relevance 0.04
NM analogues block TRPM7 currents in cultured hippocampal neurons
Negative_regulation (block) of Gene_expression (currents) of TRPM7 in neurons
7) Confidence 0.37 Published 2010 Journal Mol Brain Section Body Doc Link PMC3022637 Disease Relevance 0 Pain Relevance 0.07

General Comments

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