INT3559

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Context Info
Confidence 0.58
First Reported 1975
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 73
Total Number 75
Disease Relevance 18.89
Pain Relevance 26.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gnrhr) signal transducer activity (Gnrhr)
Anatomy Link Frequency
pituitary 12
hypothalamus 6
anterior pituitary 6
blood 4
testis 3
Gnrhr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 100 100.00 Very High Very High Very High
narcan 51 100.00 Very High Very High Very High
Opioid 28 100.00 Very High Very High Very High
Morphine 24 99.90 Very High Very High Very High
MU agonist 1 99.86 Very High Very High Very High
Endogenous opioid 16 99.84 Very High Very High Very High
Calcitonin gene-related peptide 11 99.84 Very High Very High Very High
Clonidine 66 99.82 Very High Very High Very High
Inflammation 32 99.78 Very High Very High Very High
Neuropeptide 9 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Growth Hormone Deficiency 7 100.00 Very High Very High Very High
Stress 99 99.98 Very High Very High Very High
Reprotox - General 2 3 99.96 Very High Very High Very High
Galactorrhea 2 99.92 Very High Very High Very High
Congenital Anomalies 19 99.80 Very High Very High Very High
INFLAMMATION 36 99.78 Very High Very High Very High
Growth Problems 3 99.78 Very High Very High Very High
Disease 15 99.76 Very High Very High Very High
Aging 13 99.76 Very High Very High Very High
Syndrome 16 99.58 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To investigate the mechanisms subserving the reported reduced pulsatile release of gonadotropin-releasing hormone (GnRH) in chronic renal failure, this study examined the amino acid neurotransmitter milieu in the medial preoptic area (MPOA), the hypothalamic region where the GnRH-secreting neurons reside, in 5/6-nephrectomized male rats and in ad libitum-fed or pair-fed controls.
Spec (investigate) Negative_regulation (reduced) of Localization (release) of gonadotropin-releasing hormone in medial associated with neurotransmitter, chronic renal failure and urological neuroanatomy
1) Confidence 0.58 Published 2001 Journal J. Am. Soc. Nephrol. Section Abstract Doc Link 11373345 Disease Relevance 0.71 Pain Relevance 0.15
In particular, chemotherapy (especially glucocorticosteroids and methotrexate) and cranial irradiation (apparently by reducing growth hormone secretion and by causing hypogonadotropic hypogonadism) interfere with normal bone turnover.
Negative_regulation (reducing) of Localization (secretion) of growth hormone in cranial associated with hypogonadotropic hypogonadism and methotrexate
2) Confidence 0.55 Published 2007 Journal Cancer Section Abstract Doc Link 17326055 Disease Relevance 0.56 Pain Relevance 0.13
The neurological examination found no abnormalities, but the endocrinological examination disclosed a deficiency in growth hormone secretion.
Negative_regulation (deficiency) of Localization (secretion) of growth hormone associated with congenital anomalies and growth hormone deficiency
3) Confidence 0.55 Published 1989 Journal Neurosurgery Section Abstract Doc Link 2771017 Disease Relevance 0.72 Pain Relevance 0.18
At the same time there was significant stimulation of ACTH and corticosterone release and inhibition of growth hormone release.
Negative_regulation (inhibition) of Localization (release) of growth hormone
4) Confidence 0.55 Published 1987 Journal Aust. J. Biol. Sci. Section Abstract Doc Link 3274655 Disease Relevance 0 Pain Relevance 0.66
At the same time there was significant stimulation of ACTH and corticosterone release and inhibition of growth hormone release.
Negative_regulation (inhibition) of Localization (release) of growth hormone
5) Confidence 0.55 Published 1987 Journal Aust. J. Biol. Sci. Section Abstract Doc Link 2855198 Disease Relevance 0 Pain Relevance 0.66
Somatomedin-C levels become high when the secretion of growth hormone from the adenohypophysis increases, and previous reports state that hydrocephalus decreases the secretion of growth hormone.
Negative_regulation (decreases) of Localization (secretion) of growth hormone in adenohypophysis associated with hydrocephalus
6) Confidence 0.48 Published 1998 Journal Neurosurgery Section Abstract Doc Link 9588566 Disease Relevance 0.43 Pain Relevance 0
In in vitro studies with adult male rats we have recently shown that the delta-opioid agonist DTLET inhibits the release of the Gonadotropin-Releasing Hormone (GnRH) from hypothalamic fragments containing the arcuate nucleus and the median eminence.
Negative_regulation (inhibits) of Localization (release) of Gonadotropin-Releasing Hormone in arcuate nucleus associated with mu agonist
7) Confidence 0.48 Published 1995 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 8565043 Disease Relevance 0 Pain Relevance 0.47
Corticotropin-releasing hormone (CRH) has been shown capable of inhibiting hypothalamic gonadotropin-releasing hormone (GnRH) release through activation of an endogenous opioid peptide (EOP)-dependent mechanism.
Negative_regulation (inhibiting) of Localization (release) of gonadotropin-releasing hormone associated with endogenous opioid
8) Confidence 0.46 Published 1994 Journal Neuroendocrinology Section Abstract Doc Link 7969787 Disease Relevance 0 Pain Relevance 0.32
Several studies have demonstrated that when patients self-administer SMS 201-995 from two to three times daily at home, long-term inhibition of growth hormone release and remission of the clinical symptoms of acromegaly occur without significant side effects.
Negative_regulation (inhibition) of Localization (release) of growth hormone associated with acromegaly
9) Confidence 0.43 Published 1987 Journal Am. J. Med. Section Abstract Doc Link 2884882 Disease Relevance 0.33 Pain Relevance 0.18
Impaired growth and delayed puberty in one case, and in the other hypogonadism, absence of growth hormone and gonadotrophins release in response to provocative stimuli were observed as well as abnormal thyroid stimulating hormone response to thyrotropin releasing hormone with hyperprolactinemia.
Negative_regulation (absence) of Localization (release) of growth hormone in thyroid associated with galactorrhea, reprotox - general 2 and delayed puberty
10) Confidence 0.42 Published 1989 Journal Pediatrie Section Abstract Doc Link 2662135 Disease Relevance 0.66 Pain Relevance 0.16
It is postulated that children with Down syndrome have both anatomical and biochemical hypothalamic derangements that may result in decreased growth hormone secretion and reduced linear growth.
Negative_regulation (decreased) of Localization (secretion) of growth hormone associated with down syndrome
11) Confidence 0.42 Published 1993 Journal Res Dev Disabil Section Abstract Doc Link 8210606 Disease Relevance 0.23 Pain Relevance 0.29
These and other studies suggest that prolonged stimulation of the hypothalamus by clonidine may ameliorate the impairment of growth hormone release seen in some children with constitutional growth delay.
Negative_regulation (impairment) of Localization (release) of growth hormone in hypothalamus associated with clonidine
12) Confidence 0.42 Published 1986 Journal J. Pediatr. Section Abstract Doc Link 3095519 Disease Relevance 0 Pain Relevance 0.35
Castration selectively affected PKC-coupled GnRH secretion which showed a twofold lesser release than in intact rats, while the HypGnRH release was unaffected.
Neg (unaffected) Negative_regulation (unaffected) of Localization (release) of HypGnRH
13) Confidence 0.41 Published 1998 Journal Neuroendocrinology Section Abstract Doc Link 9772343 Disease Relevance 0 Pain Relevance 0.08
Stimulation of the hypothalamic-pituitary-adrenal axis and inhibition of growth hormone release via increased central noradrenaline neuronal activity by urethane anaesthesia in the rat: blockade by clonidine.
Negative_regulation (inhibition) of Localization (release) of growth hormone in pituitary associated with anesthesia, noradrenaline and clonidine
14) Confidence 0.41 Published 1987 Journal Aust. J. Biol. Sci. Section Title Doc Link 2855198 Disease Relevance 0 Pain Relevance 0.67
Stimulation of the hypothalamic-pituitary-adrenal axis and inhibition of growth hormone release via increased central noradrenaline neuronal activity by urethane anaesthesia in the rat: blockade by clonidine.
Negative_regulation (inhibition) of Localization (release) of growth hormone in pituitary associated with anesthesia, noradrenaline and clonidine
15) Confidence 0.41 Published 1987 Journal Aust. J. Biol. Sci. Section Title Doc Link 3274655 Disease Relevance 0 Pain Relevance 0.67
Impaired growth hormone secretion in neonatal hypothyroid rats: hypothalamic versus pituitary component.
Negative_regulation (Impaired) of Localization (secretion) of growth hormone in pituitary
16) Confidence 0.40 Published 1988 Journal Proc. Soc. Exp. Biol. Med. Section Title Doc Link 3124121 Disease Relevance 0 Pain Relevance 0.05
These findings suggest that the poor linear growth in the Prader-Willi syndrome is caused by a true deficiency of growth hormone secretion, and that the low growth hormone levels observed in such cases are not an artifact of obesity.
Negative_regulation (deficiency) of Localization (secretion) of growth hormone associated with syndrome and obesity
17) Confidence 0.40 Published 1990 Journal Acta Paediatr Scand Section Abstract Doc Link 2267923 Disease Relevance 0.44 Pain Relevance 0.17
We propose that the release of ACTH and the suppression of growth hormone release following urethane anaesthesia is a result of activation of central NNA and suggest that the hormonal responses are mediated via hypothalamic noradrenergic facilitation of corticotrophin releasing factor and somatostatin release to the anterior pituitary.
Negative_regulation (suppression) of Localization (release) of growth hormone in anterior pituitary associated with somatostatin
18) Confidence 0.40 Published 1987 Journal Aust. J. Biol. Sci. Section Abstract Doc Link 2855198 Disease Relevance 0 Pain Relevance 0.66
We propose that the release of ACTH and the suppression of growth hormone release following urethane anaesthesia is a result of activation of central NNA and suggest that the hormonal responses are mediated via hypothalamic noradrenergic facilitation of corticotrophin releasing factor and somatostatin release to the anterior pituitary.
Negative_regulation (suppression) of Localization (release) of growth hormone in anterior pituitary associated with somatostatin
19) Confidence 0.40 Published 1987 Journal Aust. J. Biol. Sci. Section Abstract Doc Link 3274655 Disease Relevance 0 Pain Relevance 0.66
Impaired growth hormone secretion in VMH lesioned rats.
Negative_regulation (Impaired) of Localization (secretion) of growth hormone
20) Confidence 0.39 Published 1993 Journal Int. J. Obes. Relat. Metab. Disord. Section Title Doc Link 8101181 Disease Relevance 0 Pain Relevance 0.26

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