INT355981

Context Info Confidence 0.01 First Reported 2011 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.13 Pain Relevance 0.23

small molecule metabolic process (IDO1) cell proliferation (IFNAR2) cytosol (IDO1) extracellular space (IFNAR2) extracellular region (IFNAR2) oxidoreductase activity (IDO1)

IFNAR2 (Homo sapiens) IDO1 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 3 83.04 Central nervous system 8 81.52 Multiple sclerosis 19 66.96 Inflammation 8 56.12 headache 1 10.00 corticosteroid 1 5.00 cva 1 5.00

Disease Link Frequency Relevance Heat Disease 14 97.12 Multiple Sclerosis 5 86.84 Demyelinating Disease 20 66.96 Neurological Disease 3 57.00 INFLAMMATION 8 56.12 Recurrence 8 55.28 Infection 4 55.20 Headache 1 10.00 Injury 1 9.64 Normal Pressure Hydrocephalus 1 8.36

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Moreover, pDCs also produce indolamine 2, 3 dioxigenase (IDO), which is an enzyme activated by both type I and type II Interferon, and is involved in tryptophan catabolism.

type II Interferon Positive_regulation (activated) of IDO

1) Confidence 0.01 Published 2011 Journal J Neuroinflammation Section Body Doc Link PMC3022734 Disease Relevance 1.13 Pain Relevance 0.23

General Comments

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