INT35599

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Context Info
Confidence 0.54
First Reported 1980
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 25
Total Number 27
Disease Relevance 4.60
Pain Relevance 4.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nqo1) oxidoreductase activity (Nqo1) aging (Nqo1)
cytoplasm (Nqo1)
Anatomy Link Frequency
neurons 8
dorsal 1
molecular layer 1
aorta 1
hepatocytes 1
Nqo1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 6 100.00 Very High Very High Very High
agonist 3 100.00 Very High Very High Very High
Enkephalin 10 99.80 Very High Very High Very High
dorsal root ganglion 4 99.64 Very High Very High Very High
chemokine 9 99.16 Very High Very High Very High
Root ganglion neuron 8 97.76 Very High Very High Very High
qutenza 21 96.00 Very High Very High Very High
withdrawal 2 95.56 Very High Very High Very High
nMDA receptor antagonist 1 95.40 Very High Very High Very High
ischemia 93 93.60 High High
Disease Link Frequency Relevance Heat
Nociception 6 100.00 Very High Very High Very High
Death 6 99.90 Very High Very High Very High
Diabetes Mellitus 13 99.74 Very High Very High Very High
Ganglion Cysts 12 99.16 Very High Very High Very High
Cv General 4 Under Development 3 96.84 Very High Very High Very High
Injury 84 96.68 Very High Very High Very High
Reperfusion Injury 12 94.36 High High
Cv Unclassified Under Development 93 93.60 High High
Diabetic Neuropathy 4 90.04 High High
Heart Rate Under Development 2 88.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Infarct size was measured at 4 hours after ligation using nitroblue tetrazolium to stain for the depletion of two cytoplasmic enzymes, lactate dehydrogenase and NADPH diaphorase.
Negative_regulation (depletion) of NADPH diaphorase
1) Confidence 0.54 Published 1980 Journal J Pharmacol Methods Section Abstract Doc Link 7392665 Disease Relevance 0 Pain Relevance 0
Reduction products of NAPQI and its dimethylated analogues were not important contributors to cytotoxicity or GSSG formation based on the following results: 1) the quinone imines did not increase oxygen consumption by hepatocytes nor did they lead to oxygen uptake in solution; 2) dicoumarol, an inhibitor of the reductase, DT-diaphorase, had no effect on cytotoxicity caused by the quinone imines.
Negative_regulation (inhibitor) of DT-diaphorase in hepatocytes
2) Confidence 0.50 Published 1988 Journal Mol. Pharmacol. Section Abstract Doc Link 3173335 Disease Relevance 0 Pain Relevance 0
Intrastriatal injection of QUIN produced a dose-dependent decrease in NADPH diaphorase and enkephalin positive cells, with cell loss being evident following the injection of 6 and 18 nmol QUIN, respectively.
Negative_regulation (decrease) of NADPH diaphorase associated with enkephalin
3) Confidence 0.47 Published 1999 Journal Brain Res. Section Abstract Doc Link 9889356 Disease Relevance 0.09 Pain Relevance 0.10
In monitoring the target genes of miR-21 in the expression array at 1, 3, 7, 14 d after reperfusion, with persistent expression throughout the experiment, we detected the same 4 persistently downregulated target genes (Nqo1, Pdpn, CXCL3, and Rad23b) with the prediction algorithms miRanda and RNAhybrid, but no target gene was revealed with PicTar, TargetScanS, and MirTarget2.


Negative_regulation (downregulated) of Nqo1
4) Confidence 0.42 Published 2010 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC2894749 Disease Relevance 0.36 Pain Relevance 0.10
However, some authors suggested a deteriorating rather than a protective factor of Nqo1 in the progression of neuronal cell death, as inhibition of Nqo1 by various inhibitors protects against neuronal damage in vitro and following cerebral ischaemia in vivo [40].
Negative_regulation (inhibition) of Nqo1 in neuronal associated with cv general 4 under development and death
5) Confidence 0.42 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2894749 Disease Relevance 0.74 Pain Relevance 0.07
CXCL3: chemokine (C-X-C motif) ligand 3; miRNA: microRNA; Nqo1: NAD(P)H: quinone oxidoreductase 1; Pdpn: podoplanin; Rad23b: RAD23 homolog B.


Negative_regulation (oxidoreductase) of Nqo1 associated with chemokine
6) Confidence 0.41 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2894749 Disease Relevance 0.27 Pain Relevance 0.05
Modulation of quinolinic acid-induced depletion of striatal NADPH diaphorase and enkephalinergic neurons by inhibition of nitric oxide synthase.
Negative_regulation (depletion) of NADPH diaphorase in neurons associated with enkephalin
7) Confidence 0.41 Published 1999 Journal Brain Res. Section Title Doc Link 9889356 Disease Relevance 0.08 Pain Relevance 0.18
Both spinal neurons and primary afferent axons contributed to this bilateral increase in staining as the number of NADPH-diaphorase stained dorsal root ganglion cell bodies increased 47% over control.
Negative_regulation (number) of NADPH-diaphorase in neurons associated with ganglion cysts and dorsal root ganglion
8) Confidence 0.38 Published 1994 Journal Brain Res. Section Abstract Doc Link 8069693 Disease Relevance 0.23 Pain Relevance 0.22
These results indicate that NO formation may play a role in QUIN-induced loss of enkephalinergic neurons, but not in the loss of NADPH diaphorase neurons.
Neg (not) Negative_regulation (loss) of NADPH diaphorase in neurons
9) Confidence 0.34 Published 1999 Journal Brain Res. Section Abstract Doc Link 9889356 Disease Relevance 0.06 Pain Relevance 0.06
Pretreatment with l-NAME or 7-NI potentiated the loss of NADPH diaphorase neurons resulting from intrastriatal injection of low doses of QUIN (18 nmol).
Negative_regulation (loss) of NADPH diaphorase in neurons
10) Confidence 0.34 Published 1999 Journal Brain Res. Section Abstract Doc Link 9889356 Disease Relevance 0.08 Pain Relevance 0.08
2,3-Dimethoxy 1,4-naphthoquinone (DMNQ), which redox cycles via two-electron reduction, mediates reduction of the cell-impermeative tetrazolium dye WST-1 in kidney epithelial cells (MDCK), which express high levels of NQO1, but not in HL60 or CHO cells, which are NQO1 deficient.
Negative_regulation (deficient) of NQO1 in MDCK
11) Confidence 0.33 Published 2010 Journal Free Radic. Biol. Med. Section Abstract Doc Link 19932748 Disease Relevance 0 Pain Relevance 0.09
Neither NOS inhibitor had any effect on the loss of striatal NADPH diaphorase neurons induced by a higher dose of QUIN (24 nmol).
Negative_regulation (loss) of NADPH diaphorase in neurons
12) Confidence 0.30 Published 1999 Journal Brain Res. Section Abstract Doc Link 9889356 Disease Relevance 0.08 Pain Relevance 0.07
Distribution of NADPH-diaphorase and AChE activity in the anterior leaflet of rat mitral valve.
Negative_regulation (Distribution) of NADPH-diaphorase in anterior
13) Confidence 0.27 Published 2010 Journal Eur J Histochem Section Title Doc Link 20353912 Disease Relevance 0.07 Pain Relevance 0.19
STZ-induced diabetic rats showed decreases in nociceptive threshold and NADPH-diaphorase positive neurons, nNOS level and cGMP content of DRG at 12 weeks after induction of diabetes.
Negative_regulation (decreases) of NADPH-diaphorase in neurons associated with nociception and diabetes mellitus
14) Confidence 0.24 Published 1999 Journal Rinsho Shinkeigaku Section Abstract Doc Link 10377817 Disease Relevance 0.89 Pain Relevance 0.19
The number of NADPH-diaphorase positive neurons was significantly decreased in untreated diabetic compared with control rats.
Negative_regulation (decreased) of NADPH-diaphorase in neurons associated with diabetes mellitus
15) Confidence 0.18 Published 1998 Journal Neuroreport Section Abstract Doc Link 9507963 Disease Relevance 0.81 Pain Relevance 0.38
Down-regulation of NADPH-diaphorase (nitric oxide synthase) may account for the pharmacological activities of Cu(II)2 (3,5-diisopropylsalicylate)4.
Negative_regulation (Down-regulation) of NADPH-diaphorase
16) Confidence 0.17 Published 1995 Journal J. Inorg. Biochem. Section Title Doc Link 8530918 Disease Relevance 0 Pain Relevance 0.12
Investigation of the patient and her family showed that the methaemoglobinaemia resulted from a recessive deficiency of NADH-diaphorase enzyme.
Negative_regulation (deficiency) of NADH-diaphorase
17) Confidence 0.16 Published 1998 Journal Intensive Care Med Section Abstract Doc Link 9722041 Disease Relevance 0 Pain Relevance 0
Seven days after sciatic transection the induction of reduced nicotinamide adenine dinucleotide phosphate diaphorase and nitric oxide synthase messenger RNA found in the vehicle-treated group was not observed in the capsaicin group.
Negative_regulation (reduced) of diaphorase associated with qutenza
18) Confidence 0.14 Published 1995 Journal Neuroscience Section Abstract Doc Link 7539899 Disease Relevance 0.33 Pain Relevance 0.73
The distribution of c-fos expression and NADPH-diaphorase reactivity in the cervical and lumbar segments after stimulation of the vanilloid receptors in the dorsal neck muscles with capsaicin was studied in cats anaesthetized with alpha-chloralose.
Negative_regulation (distribution) of NADPH-diaphorase in dorsal associated with qutenza
19) Confidence 0.12 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16168409 Disease Relevance 0 Pain Relevance 0.38
NADPH-diaphorase reactivity is reduced in the molecular layer but increased in the granular layer of primate cerebellum after prolonged anaesthesia.
Negative_regulation (reduced) of NADPH-diaphorase in molecular layer associated with anesthesia
20) Confidence 0.12 Published 1997 Journal Neurosci. Lett. Section Title Doc Link 9259480 Disease Relevance 0 Pain Relevance 0.10

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