INT3560

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Context Info
Confidence 0.40
First Reported 1975
Last Reported 1991
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.44
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gh1) signal transduction (Gh1) mitochondrion (Gh1)
extracellular space (Gh1) extracellular region (Gh1) plasma membrane (Gh1)
Anatomy Link Frequency
plasma 2
pituitary 2
Gh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 1 100.00 Very High Very High Very High
anesthesia 3 94.24 High High
Somatostatin 1 86.40 High High
dexamethasone 4 84.20 Quite High
narcan 4 76.12 Quite High
opiate 4 75.00 Quite High
Disease Link Frequency Relevance Heat
Obesity 32 99.84 Very High Very High Very High
Body Weight 1 98.12 Very High Very High Very High
Congenital Anomalies 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In both sexes, the GH response to each dose of GRF tested was decreased in the obese group.
Negative_regulation (decreased) of Regulation (response) of GH associated with obesity
1) Confidence 0.40 Published 1989 Journal Neuroendocrinology Section Abstract Doc Link 2510049 Disease Relevance 0.64 Pain Relevance 0.09
Further, the GH response to either rat GH-releasing factor (5 mu/kg) or morphine (1 mg/kg) were reduced in obese male rats.
Negative_regulation (reduced) of Regulation (response) of GH associated with obesity and morphine
2) Confidence 0.38 Published 1991 Journal Growth Dev Aging Section Abstract Doc Link 1682282 Disease Relevance 0.78 Pain Relevance 0.10
In contrast, the GH response to all GRF concentrations tested was significantly decreased in the 8-week-old obese rats as compared to their respective lean siblings.
Negative_regulation (decreased) of Regulation (response) of GH associated with obesity
3) Confidence 0.38 Published 1990 Journal Regul. Pept. Section Abstract Doc Link 2139233 Disease Relevance 1.02 Pain Relevance 0.11
T3 also antagonized the pentobarbital-induced release of GH; however, plasma B levels were not modified, and the effect on plasma GH levels was not suppressed by propranolol.
Neg (not) Negative_regulation (suppressed) of Regulation (effect) of GH in plasma
4) Confidence 0.35 Published 1975 Journal Endocr Res Commun Section Abstract Doc Link 806447 Disease Relevance 0 Pain Relevance 0.08
Our results are consistent with both a role of pituitary beta-END in the control of GH and a role of corticosterone in the control of PRL during suckling.
Negative_regulation (role) of Regulation (control) of GH in pituitary
5) Confidence 0.23 Published 1984 Journal Endocrinology Section Abstract Doc Link 6323136 Disease Relevance 0 Pain Relevance 0.47

General Comments

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