INT356058

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.23
First Reported 2011
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.80
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Adam10) nucleocytoplasmic transport (Adam10) Golgi apparatus (Adam10)
nucleus (Adam10) cytoplasm (Adam10)
Anatomy Link Frequency
platelets 2
neurons 1
neural 1
Adam10 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 8 72.80 Quite High
Kinase C 24 5.00 Very Low Very Low Very Low
sodium channel 8 5.00 Very Low Very Low Very Low
long-term potentiation 4 5.00 Very Low Very Low Very Low
Nerve growth factor 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
amygdala 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Neuronal excitability 4 5.00 Very Low Very Low Very Low
nMDA receptor 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 152 100.00 Very High Very High Very High
Necrosis 4 81.48 Quite High
Cancer 4 81.12 Quite High
Stress 4 46.08 Quite Low
Congenital Anomalies 16 31.44 Quite Low
Targeted Disruption 36 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 20 5.00 Very Low Very Low Very Low
Syndrome 20 5.00 Very Low Very Low Very Low
Amyloid Plaque 16 5.00 Very Low Very Low Very Low
Death 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-secretase activity in human neurons [48], whereas RNAi downregulation of ADAM10 had no effect on ?
Negative_regulation (downregulation) of ADAM10 in neurons
1) Confidence 0.23 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.16 Pain Relevance 0.07
A dramatically reduced ADAM10 protein level in the platelets of sporadic AD patients was also found to correlate with the significantly decreased sAPP?
Negative_regulation (correlate) of ADAM10 in platelets associated with disease
2) Confidence 0.23 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.19 Pain Relevance 0
A dramatically reduced ADAM10 protein level in the platelets of sporadic AD patients was also found to correlate with the significantly decreased sAPP?
Negative_regulation (reduced) of ADAM10 in platelets associated with disease
3) Confidence 0.23 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.18 Pain Relevance 0
generation was nearly abolished in the neurons of mice with neural ADAM10 conditionally knocked-out [54].
Negative_regulation (abolished) of ADAM10 in neural
4) Confidence 0.20 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.27 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox