INT356106

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Context Info
Confidence 0.29
First Reported 2011
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.21
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Pld1, App) endosome (Pld1) cell adhesion (App)
plasma membrane (App) extracellular matrix organization (App) DNA binding (App)
Anatomy Link Frequency
vesicles 2
Pld1 (Mus musculus)
App (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 6 5.00 Very Low Very Low Very Low
sodium channel 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
long-term potentiation 1 5.00 Very Low Very Low Very Low
Nerve growth factor 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
amygdala 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Neuronal excitability 1 5.00 Very Low Very Low Very Low
nMDA receptor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 38 91.84 High High
Targeted Disruption 9 61.92 Quite High
Alzheimer's Dementia 5 5.00 Very Low Very Low Very Low
Syndrome 5 5.00 Very Low Very Low Very Low
Congenital Anomalies 4 5.00 Very Low Very Low Very Low
Amyloid Plaque 4 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low
Adhesions 3 5.00 Very Low Very Low Very Low
Cognitive Disorder 3 5.00 Very Low Very Low Very Low
Drug Induced Neurotoxicity 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This PS1-PLD1 interaction recruits PLD1 to the Golgi/TGN and thus potentially alters APP trafficking as PLD1 overexpression promotes budding of vesicles from the TGN containing APP and increases cell surface levels of APP [176,177].
Gene_expression (overexpression) of PLD1 in vesicles Positive_regulation (increases) of APP
1) Confidence 0.29 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.21 Pain Relevance 0

General Comments

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