INT35612

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Context Info
Confidence 0.78
First Reported 1988
Last Reported 2010
Negated 4
Speculated 4
Reported most in Abstract
Documents 37
Total Number 41
Disease Relevance 33.33
Pain Relevance 10.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (REG3A) extracellular space (REG3A) extracellular region (REG3A)
cytoplasm (REG3A)
Anatomy Link Frequency
pancreas 6
liver 2
hip 2
joint 1
medial 1
REG3A (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 18 100.00 Very High Very High Very High
cytokine 12 99.60 Very High Very High Very High
fibrosis 7 99.34 Very High Very High Very High
interstitial cystitis 8 99.28 Very High Very High Very High
Chronic pancreatitis 122 99.16 Very High Very High Very High
rheumatoid arthritis 2 97.60 Very High Very High Very High
Pain 8 86.00 High High
Paracetamol 6 83.12 Quite High
imagery 51 82.88 Quite High
backache 2 50.00 Quite Low
Disease Link Frequency Relevance Heat
Pancreatitis 231 100.00 Very High Very High Very High
Targeted Disruption 13 100.00 Very High Very High Very High
Cancer 163 99.84 Very High Very High Very High
Disease 20 99.44 Very High Very High Very High
Fibrosis 7 99.34 Very High Very High Very High
Interstitial Cystitis 8 99.28 Very High Very High Very High
INFLAMMATION 11 99.08 Very High Very High Very High
Pancreatic Cancer 102 98.92 Very High Very High Very High
Adenocarcinoma 61 98.88 Very High Very High Very High
Aseptic Necrosis Of Bone 3 98.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PAP overexpression was significantly correlated with nodal involvement, distant metastasis (P < 0.05), and short survival (P < 0.01) in pancreatic cancer.
Gene_expression (overexpression) of PAP associated with pancreatic cancer and metastasis
1) Confidence 0.78 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 12757156 Disease Relevance 1.49 Pain Relevance 0.18
Overexpression of pancreatitis-associated protein (PAP) in human pancreatic ductal adenocarcinoma.
Gene_expression (Overexpression) of pancreatitis-associated protein associated with adenocarcinoma and pancreatitis
2) Confidence 0.78 Published 2003 Journal Dig. Dis. Sci. Section Title Doc Link 12757156 Disease Relevance 1.43 Pain Relevance 0.15
Overexpression of pancreatitis-associated protein (PAP) in human pancreatic ductal adenocarcinoma.
Gene_expression (Overexpression) of PAP associated with adenocarcinoma and pancreatitis
3) Confidence 0.78 Published 2003 Journal Dig. Dis. Sci. Section Title Doc Link 12757156 Disease Relevance 1.43 Pain Relevance 0.15
PAP was overexpressed in 79% (30 of 38) of pancreatic ductal adenocarcinoma, 19% (7 of 36) of chronic pancreatitis, and 29% (2 of 7) of mucinous cystadenoma.
Gene_expression (overexpressed) of PAP associated with mucinous cystadenoma, adenocarcinoma and chronic pancreatitis
4) Confidence 0.78 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 12757156 Disease Relevance 1.48 Pain Relevance 0.18
The incidence of PAP overexpression was significantly higher in pancreatic cancer than in the other pancreatic diseases (P < 0.01).
Gene_expression (overexpression) of PAP associated with pancreatitis and pancreatic cancer
5) Confidence 0.78 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 12757156 Disease Relevance 1.52 Pain Relevance 0.19
These results suggest that overexpression of PAP in human pancreatic ductal adenocarcinoma indicates tumor aggressiveness.
Gene_expression (overexpression) of PAP associated with adenocarcinoma, cancer and aggression
6) Confidence 0.78 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 12757156 Disease Relevance 1.69 Pain Relevance 0.16
We examined PAP expression in pancreatic tissues from individuals with pancreatic ductal adenocarcinoma using immunohistochemistry.
Spec (examined) Gene_expression (expression) of PAP associated with adenocarcinoma
7) Confidence 0.78 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 12757156 Disease Relevance 1.30 Pain Relevance 0.15
In contrast, overexpression of human HIP/PAP promoted liver resistance to Fas and accelerated liver regeneration with early activation/deactivation of STAT3.
Gene_expression (overexpression) of HIP in liver
8) Confidence 0.75 Published 2006 Journal Hepatology Section Abstract Doc Link 17133485 Disease Relevance 0.35 Pain Relevance 0
In contrast, overexpression of human HIP/PAP promoted liver resistance to Fas and accelerated liver regeneration with early activation/deactivation of STAT3.
Gene_expression (overexpression) of PAP in liver
9) Confidence 0.75 Published 2006 Journal Hepatology Section Abstract Doc Link 17133485 Disease Relevance 0.35 Pain Relevance 0
PAP mRNA is also expressed in cancer cells, including pancreatic ductal adenocarcinoma.
Gene_expression (expressed) of PAP associated with adenocarcinoma and cancer
10) Confidence 0.68 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 12757156 Disease Relevance 1.10 Pain Relevance 0.12
CONCLUSION: Although there is lack of causality between LBP and hip rotation, the deficit in lead leg medial hip rotation in amateur golfers who suffer LBP may be relevant for screening or treatment selection.


Gene_expression (rotation) of hip in medial
11) Confidence 0.65 Published 2009 Journal Phys Ther Sport Section Body Doc Link 19897166 Disease Relevance 0.05 Pain Relevance 0
Therefore we suggest that ELISA measurements of serum HIP/HAP and MUC-1 levels could be added to a panel of tests for the routine screening of population to identify individuals at increased risk for the developing pancreatic carcinoma.
Gene_expression (levels) of HIP associated with pancreatic cancer
12) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776527 Disease Relevance 0.97 Pain Relevance 0.21
In contrast, HIP/PAP transgenic mice were resistant to Fas, with HIP/PAP serving as a sulfhydryl buffer to slow down decreases in glutathione and Bcl-xL.
Gene_expression (resistant) of HIP associated with targeted disruption
13) Confidence 0.65 Published 2006 Journal Hepatology Section Abstract Doc Link 17133485 Disease Relevance 0.52 Pain Relevance 0.08
In contrast, HIP/PAP transgenic mice were resistant to Fas, with HIP/PAP serving as a sulfhydryl buffer to slow down decreases in glutathione and Bcl-xL.
Gene_expression (resistant) of HIP associated with targeted disruption
14) Confidence 0.65 Published 2006 Journal Hepatology Section Abstract Doc Link 17133485 Disease Relevance 0.53 Pain Relevance 0.08
In contrast, HIP/PAP transgenic mice were resistant to Fas, with HIP/PAP serving as a sulfhydryl buffer to slow down decreases in glutathione and Bcl-xL.
Gene_expression (resistant) of PAP associated with targeted disruption
15) Confidence 0.65 Published 2006 Journal Hepatology Section Abstract Doc Link 17133485 Disease Relevance 0.52 Pain Relevance 0.08
Our results demonstrate that hip aspiration is only of assistance if there is any conspicuous preoperative sign such as an open wound or sinus in communication with the joint or in case of elevated C-reactive protein which could not be explained by other conditions what is corresponding to the experience of other authors [2].
Gene_expression (aspiration) of hip in joint associated with injury
16) Confidence 0.65 Published 2008 Journal J Orthop Surg Section Body Doc Link PMC2492844 Disease Relevance 0.44 Pain Relevance 0
The immunohistochemical detection of lactoferrin was carried out with the PAP technique on pancreatic tissue samples of 23 patients, operated for acute (13) or chronic (4) pancreatitis as well as for adenocarcinomas (6).
Gene_expression (detection) of PAP associated with adenocarcinoma and pancreatitis
17) Confidence 0.65 Published 1993 Journal Acta Histochem. Section Abstract Doc Link 8279235 Disease Relevance 0.31 Pain Relevance 0.03
[Murata-Chiba (MC) support ring for acetabular defect in rheumatoid hip].
Gene_expression (defect) of hip in hip
18) Confidence 0.65 Published 1996 Journal Ryumachi Section Title Doc Link 8779796 Disease Relevance 0.17 Pain Relevance 0.12
Pancreatitis-associated protein (PAP) is almost absent in normal pancreas, but is strongly induced in acute pancreatitis.
Neg (absent) Gene_expression (absent) of PAP in pancreas associated with pancreatitis
19) Confidence 0.60 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 12757156 Disease Relevance 0.98 Pain Relevance 0.06
These 20 genes included pancreatitis-associated protein (HIP/PAP), a gene known to be overexpressed in acini adjacent to infiltrating pancreatic cancer, and the gene cartilage glycoprotein-39 (HC gp-39 or TKL-40).
Gene_expression (overexpressed) of PAP in cartilage associated with pancreatic cancer and pancreatitis
20) Confidence 0.58 Published 2005 Journal Mod. Pathol. Section Abstract Doc Link 15791284 Disease Relevance 1.16 Pain Relevance 0.45

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