INT356220

Context Info Confidence 0.32 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 5 Disease Relevance 1.48 Pain Relevance 1.74

transport (Slc32a1)

Anatomy Link Frequency liver 1 muscle 1 lung 1 Slc32a1 (Mus musculus)

Pain Link Frequency Relevance Heat Spinal cord 80 99.88 GABAergic 70 95.88 nMDA receptor antagonist 10 94.68 gABA 205 94.08 Glutamate receptor 5 90.00 antagonist 10 73.44 monoamine 20 36.08 Glutamate 35 28.00 Neurotransmitter 30 24.88 Somatostatin 5 9.84

Disease Link Frequency Relevance Heat Body Weight 15 100.00 Targeted Disruption 180 98.00 Cleft Palate 80 93.12 Umbilical Hernia 120 92.00 Frailty 10 19.52 Death 15 7.68 Congenital Anomalies 20 5.00 Respiratory Failure 15 5.00 Generalized Anxiety Disorder 15 5.00 Anxiety Disorder 15 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Alterations in body weight, response to stimuli, trapezius muscle, liver and lung of VGAT-/- mice

VGAT Binding (Alterations) of in muscle associated with body weight

1) Confidence 0.32 Published 2010 Journal Mol Brain Section Body Doc Link PMC3023674 Disease Relevance 0.41 Pain Relevance 0.39

Contribution of VGAT to motor function

VGAT Binding (Contribution) of

2) Confidence 0.32 Published 2010 Journal Mol Brain Section Body Doc Link PMC3023674 Disease Relevance 0.07 Pain Relevance 0.56

We then intercrossed VGAT+/- mice to generate VGAT-/- mice.

VGAT Binding (intercrossed) of

3) Confidence 0.32 Published 2010 Journal Mol Brain Section Body Doc Link PMC3023674 Disease Relevance 0.17 Pain Relevance 0

Alterations in body weight, response to stimuli, trapezius muscle, liver and lung of VGAT-/- mice

VGAT Binding (Alterations) of in liver associated with body weight

4) Confidence 0.11 Published 2010 Journal Mol Brain Section Body Doc Link PMC3023674 Disease Relevance 0.41 Pain Relevance 0.39

Alterations in body weight, response to stimuli, trapezius muscle, liver and lung of VGAT-/- mice

VGAT Binding (Alterations) of in lung associated with body weight

5) Confidence 0.11 Published 2010 Journal Mol Brain Section Body Doc Link PMC3023674 Disease Relevance 0.41 Pain Relevance 0.39

General Comments

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