INT356226

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Context Info
Confidence 0.06
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.28
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Acot1) mitochondrion (Acot1) lipid metabolic process (Acot1)
cytoplasm (Acot1)
Acot1 (Mus musculus)
Pain Link Frequency Relevance Heat
GABAergic 14 97.76 Very High Very High Very High
gABA 41 96.56 Very High Very High Very High
monoamine 4 92.00 High High
Glutamate 7 83.92 Quite High
Neurotransmitter 6 80.80 Quite High
Spinal cord 16 5.00 Very Low Very Low Very Low
Central nervous system 5 5.00 Very Low Very Low Very Low
nMDA receptor antagonist 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 36 99.52 Very High Very High Very High
Umbilical Hernia 24 42.60 Quite Low
Cleft Palate 16 42.00 Quite Low
Congenital Anomalies 4 5.00 Very Low Very Low Very Low
Respiratory Failure 3 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low
Generalized Anxiety Disorder 3 5.00 Very Low Very Low Very Low
Body Weight 3 5.00 Very Low Very Low Very Low
Anxiety Disorder 3 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In VAChT knockout mice the amount of the ACh-synthesizing enzyme choline acetyltransferase (ChAT) is increased at the mRNA and protein levels compared to their wild-type littermates, suggesting that the change in ChAT expression may be related to a compensatory mechanism due to the lack of ACh release [16].
Positive_regulation (increased) of Transcription (mRNA) of ACh-synthesizing associated with targeted disruption
1) Confidence 0.06 Published 2010 Journal Mol Brain Section Body Doc Link PMC3023674 Disease Relevance 0.28 Pain Relevance 0.54

General Comments

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