INT356231

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Context Info
Confidence 0.32
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.25
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Gad1) transport (Gabrb3) lyase activity (Gad1)
intracellular (Gad1) plasma membrane (Gabrb3) cytoplasm (Gad1)
Anatomy Link Frequency
palate 1
Gabrb3 (Mus musculus)
Gad1 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 41 100.00 Very High Very High Very High
Spinal cord 16 74.40 Quite High
medulla 1 73.12 Quite High
GABAergic 14 12.24 Low Low
Glutamate 7 5.00 Very Low Very Low Very Low
Neurotransmitter 6 5.00 Very Low Very Low Very Low
Central nervous system 5 5.00 Very Low Very Low Very Low
monoamine 4 5.00 Very Low Very Low Very Low
nMDA receptor antagonist 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cleft Palate 16 100.00 Very High Very High Very High
Targeted Disruption 36 99.60 Very High Very High Very High
Umbilical Hernia 24 96.20 Very High Very High Very High
Congenital Anomalies 4 61.20 Quite High
Anxiety Disorder 3 58.80 Quite High
Muscle Hypertonia 1 57.12 Quite High
Apoptosis 2 45.68 Quite Low
Inguinal Hernia 1 41.28 Quite Low
Frailty 2 40.48 Quite Low
Death 3 37.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Concerning the mechanism of onset of cleft palate, studies using knockout mice have revealed associations between cleft palate and mutation of genes related to GABA signaling, such as GAD67 and GABRB3 [8,23,38].
GABRB3 Binding (associations) of GAD67 in palate associated with targeted disruption, gaba and cleft palate
1) Confidence 0.32 Published 2010 Journal Mol Brain Section Body Doc Link PMC3023674 Disease Relevance 1.25 Pain Relevance 0.23

General Comments

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