INT356275

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.21
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mapk1) mitochondrion (Mapk1) Golgi apparatus (Mapk1)
protein complex (Mapk1) microtubule organizing center (Mapk1) cytoplasm (Mapk1)
Anatomy Link Frequency
neurons 2
Gdnf (Rattus norvegicus)
Mapk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 26 60.88 Quite High
agonist 8 59.20 Quite High
Hyperalgesia 28 5.00 Very Low Very Low Very Low
nociceptor 22 5.00 Very Low Very Low Very Low
withdrawal 12 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
Kinase C 4 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
Nerve growth factor 2 5.00 Very Low Very Low Very Low
sodium channel 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Wound Healing 6 90.60 High High
Pain 26 60.88 Quite High
Nociception 44 53.76 Quite High
Starvation 4 25.68 Quite Low
Hyperalgesia 28 5.00 Very Low Very Low Very Low
INFLAMMATION 6 5.00 Very Low Very Low Very Low
Cancer 4 5.00 Very Low Very Low Very Low
Injury 4 5.00 Very Low Very Low Very Low
Poisoning 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to the growth factors NGF and GDNF, EGF failed to induce Erk1/2 phosphorylation even though the EGFR is expressed in all DRG-neurons and the STAT3 signalling pathway is initiated by EGF in DRG-neurons.
GDNF Neg (failed) Positive_regulation (induce) of Phosphorylation (phosphorylation) of Erk1/2 in neurons
1) Confidence 0.05 Published 2010 Journal Mol Pain Section Body Doc Link PMC3023724 Disease Relevance 0.09 Pain Relevance 0.03
Also GDNF resulted in phosphorylation of Erk1/2.
GDNF Positive_regulation (resulted) of Phosphorylation (phosphorylation) of Erk1/2
2) Confidence 0.04 Published 2010 Journal Mol Pain Section Body Doc Link PMC3023724 Disease Relevance 0.11 Pain Relevance 0.06

General Comments

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