INT356317

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Context Info
Confidence 0.18
First Reported 2011
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.65
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Crhr1) plasma membrane (Crhr1) response to stress (Crhr1)
signal transducer activity (Crhr1)
Crhr1 (Mus musculus)
Cea (Mus musculus)
Pain Link Frequency Relevance Heat
amygdala 102 100.00 Very High Very High Very High
GABAergic 32 100.00 Very High Very High Very High
gABA 48 96.72 Very High Very High Very High
addiction 16 82.28 Quite High
alcohol 22 81.88 Quite High
tolerance 2 60.48 Quite High
Neurotransmitter 8 57.60 Quite High
withdrawal 4 56.80 Quite High
opiate 2 55.88 Quite High
antagonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 10 93.00 High High
Alcohol Addiction 16 89.12 High High
Recurrence 2 62.16 Quite High
Stress 4 61.16 Quite High
Fetal Death 2 5.00 Very Low Very Low Very Low
Depression 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we used male HET mice with diminished AC7 activity (Hines et al., 2006) to investigate a role of AC in ethanol- and CRF1-dependent effects on GABAergic transmission in the CeA.
CRF1 Spec (investigate) Regulation (effects) of Gene_expression (transmission) of CeA associated with gabaergic and amygdala
1) Confidence 0.18 Published 2011 Journal Frontiers in Neuroscience Section Body Doc Link PMC3024005 Disease Relevance 0.27 Pain Relevance 0.72
We identified AC7 as a critical signaling effector molecule involved in the ethanol and CRF1 effects on GABAergic transmission in the CeA.
CRF1 Regulation (effects) of Gene_expression (transmission) of CeA associated with gabaergic and amygdala
2) Confidence 0.18 Published 2011 Journal Frontiers in Neuroscience Section Body Doc Link PMC3024005 Disease Relevance 0.38 Pain Relevance 0.61

General Comments

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