INT356320

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Context Info
Confidence 0.01
First Reported 2011
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.05
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prkaca) Golgi apparatus (Prkaca) protein complex (Prkaca)
cytoplasm (Prkaca) nucleus (Prkaca) plasma membrane (Prkaca)
ORF61 (Mus musculus)
Prkaca (Mus musculus)
Pain Link Frequency Relevance Heat
amygdala 51 100.00 Very High Very High Very High
GABAergic 16 92.80 High High
gABA 24 82.32 Quite High
Neurotransmitter 4 72.24 Quite High
alcohol 11 66.48 Quite High
tolerance 1 65.84 Quite High
addiction 8 64.80 Quite High
withdrawal 2 6.24 Low Low
opiate 1 5.32 Low Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alcohol Addiction 8 53.68 Quite High
Anxiety Disorder 5 42.44 Quite Low
Recurrence 1 11.60 Low Low
Stress 2 10.60 Low Low
Fetal Death 1 5.00 Very Low Very Low Very Low
Depression 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Given the sensitivity of AC7 to ethanol and the coupling of AC7 to CRF1, our findings suggest that AC7 responds to ethanol and CRF in the CeA by increasing cAMP signaling and subsequent activation of the PKA cascade.
AC7 Positive_regulation (increasing) of Positive_regulation (activation) of PKA associated with amygdala
1) Confidence 0.01 Published 2011 Journal Frontiers in Neuroscience Section Body Doc Link PMC3024005 Disease Relevance 0.05 Pain Relevance 0.57

General Comments

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