INT35634

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Context Info
Confidence 0.37
First Reported 1988
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 12
Disease Relevance 3.23
Pain Relevance 3.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Sds) lyase activity (Sds) cellular_component (Sds)
cellular amino acid metabolic process (Sds) cytoplasm (Sds)
Anatomy Link Frequency
neurons 6
neuronal 2
postsynaptic membrane 2
synapses 2
SDH 2
Sds (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn 624 100.00 Very High Very High Very High
spinal dorsal horn 6 100.00 Very High Very High Very High
ASIC 5 100.00 Very High Very High Very High
Paracetamol 5 99.98 Very High Very High Very High
Neuronal excitability 42 99.96 Very High Very High Very High
Glutamate 42 98.56 Very High Very High Very High
IPN 1 96.92 Very High Very High Very High
Pain 11 92.16 High High
Peripheral nerve injury 96 86.88 High High
Action potential 108 85.12 High High
Disease Link Frequency Relevance Heat
Nervous System Injury 552 99.96 Very High Very High Very High
Neuropathic Pain 150 99.40 Very High Very High Very High
Inflammatory Pain 2 96.92 Very High Very High Very High
Hepatotoxicity 2 92.92 High High
Pain 15 92.16 High High
Hypersensitivity 15 75.00 Quite High
Aging 10 75.00 Quite High
Nociception 13 56.16 Quite High
Sperm Disorder 6 52.72 Quite High
Apoptosis 3 50.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both doses of acetaminophen produced significant elevations of serum alanine aminotransferase (ALT) and sorbitol dehydrogenase (SDH) activities in 4-month-old rats.
Positive_regulation (elevations) of Gene_expression (produced) of SDH associated with paracetamol
1) Confidence 0.37 Published 1988 Journal Drug Chem Toxicol Section Abstract Doc Link 3181038 Disease Relevance 0.24 Pain Relevance 0.42
However, the cellular distribution and the functional consequence of increased ASIC subunit expression in the SDH remain unclear.
Positive_regulation (increased) of Gene_expression (expression) of SDH in SDH associated with spinal dorsal horn and asic
2) Confidence 0.28 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17928456 Disease Relevance 0.61 Pain Relevance 1.00
There were evidences that the levels of SDH, SOD, GSH, AST, ALT were significantly increased by a taurine supplement in serum, and the level of MDA decreased [32-35].
Positive_regulation (increased) of Gene_expression (levels) of SDH
3) Confidence 0.23 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994374 Disease Relevance 0.10 Pain Relevance 0
As shown in Fig.4, the levels of SOD, ACP, SDH, NOS and NO were obviously increased by taurine administration in adult rats, the levels of AKP, AST and ALT were significantly decreased, but the levels of MDA, LDH and GSH had no changes.
Positive_regulation (increased) of Gene_expression (levels) of SDH
4) Confidence 0.23 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994374 Disease Relevance 0 Pain Relevance 0
The levels of SOD, ACP, LDH, SDH, NOS, NO and GSH were significantly elevated by taurine administration in aged rats, the levels of AST and ALT were significantly decreased, but the levels of AKP and MDA had no changes.
Positive_regulation (elevated) of Gene_expression (levels) of SDH
5) Confidence 0.23 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994374 Disease Relevance 0 Pain Relevance 0
Thus, an increase in TNFR1 expression in SDH neurons under neuropathic conditions could increase the number of functional synapses via AMPAR insertion into the postsynaptic membrane and thus potentiate glutamatergic signaling.
Positive_regulation (increase) of Gene_expression (expression) of SDH in postsynaptic membrane associated with neuropathic pain and dorsal horn
6) Confidence 0.22 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657778 Disease Relevance 0.10 Pain Relevance 0.26
increased the spontaneous and miniature EPSC frequency in adult SDH neurons within minutes [16,17], neither acute nor prolonged bath application of TNF?
Positive_regulation (increased) of Gene_expression (neurons) of SDH in neurons associated with dorsal horn
7) Confidence 0.19 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657778 Disease Relevance 0.35 Pain Relevance 0.47
causes selective changes in the intrinsic membrane properties of immature SDH neurons which increase neuronal excitability, but these alterations only occur under neuropathic conditions.


Positive_regulation (increase) of Gene_expression (neurons) of SDH in neuronal associated with neuronal excitability, neuropathic pain and dorsal horn
8) Confidence 0.19 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657778 Disease Relevance 0.85 Pain Relevance 0.46
failed to increase the efficacy of excitatory synapses in the neonatal SDH (Figure 3), as there was no significant difference in mean mEPSC frequency in the presence of TNF?
Neg (failed) Positive_regulation (increase) of Gene_expression (neonatal) of SDH in synapses associated with dorsal horn
9) Confidence 0.19 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657778 Disease Relevance 0.59 Pain Relevance 0.33
It seems surprising that, despite facilitating spontaneous excitatory transmission (Figure 1) and decreasing the PPR of the evoked EPSCs (Figure 5) in neonatal SDH neurons after SNI, TNF?
Positive_regulation (after) of Gene_expression (neurons) of SDH in neurons associated with nervous system injury and dorsal horn
10) Confidence 0.19 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657778 Disease Relevance 0.31 Pain Relevance 0.54
treatment (Figure 1) also partially reflects an increase in the surface expression of AMPARs within SDH neurons.
Positive_regulation (increase) of Gene_expression (expression) of SDH in neurons associated with dorsal horn
11) Confidence 0.18 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657778 Disease Relevance 0.08 Pain Relevance 0.22
Maximum levels of SDS bound to proteins (or peptides) occur at ?
Positive_regulation (occur) of Gene_expression (levels) of SDS
12) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2805716 Disease Relevance 0 Pain Relevance 0

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