INT356350

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 4.31
Pain Relevance 4.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Snf8) nucleus (Snf8) molecular_function (Snf8)
transcription factor binding (Snf8) cellular_component (Snf8) biological_process (Snf8)
Snf8 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
headache 234 100.00 Very High Very High Very High
withdrawal 18 97.08 Very High Very High Very High
Migraine 93 96.32 Very High Very High Very High
central sensitization 30 94.12 High High
allodynia 3 90.52 High High
Triptan 45 86.64 High High
cINOD 63 82.24 Quite High
Pain 15 78.80 Quite High
Pain matrix 3 65.80 Quite High
IPN 3 24.72 Low Low
Disease Link Frequency Relevance Heat
Headache 288 100.00 Very High Very High Very High
Nociception 12 99.60 Very High Very High Very High
Neuropathic Pain 3 90.52 High High
INFLAMMATION 6 84.16 Quite High
Headache Disorders 15 80.32 Quite High
Migraine Disorders 3 79.60 Quite High
Pain 21 78.80 Quite High
Migraine Without Aura 30 77.24 Quite High
Recurrence 6 30.84 Quite Low
Inflammatory Pain 3 24.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
According to the revised ICHD-II criteria [1], 29 patients (35 ± 11 years; 23 women) were diagnosed as having MOH during their first visit, a diagnosis that was confirmed 2 months after withdrawal treatment.
Positive_regulation (having) of MOH associated with headache and withdrawal
1) Confidence 0.02 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3024248 Disease Relevance 1.17 Pain Relevance 1.30
Our finding that the SEP amplitude increase in MOH is proportional to the duration of headache chronification suggests that medication overuse and increased headache frequency promote or reinforce central sensitization, but leaves open the question of the culprit.
Positive_regulation (increase) of MOH associated with central sensitization and headache
2) Confidence 0.02 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3024248 Disease Relevance 1.57 Pain Relevance 1.55
It is associated with increased nociceptive reflexes [26,27], but, interestingly, in MOH trigeminal evoked potentials were increased, whereas nociceptive blink reflexes remained unchanged, suggesting as in our study that sensitization takes place at supraspinal levels [28].
Positive_regulation (increased) of MOH associated with nociception and headache
3) Confidence 0.02 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3024248 Disease Relevance 1.56 Pain Relevance 1.37

General Comments

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