INT35636

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Context Info
Confidence 0.78
First Reported 1982
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.31
Pain Relevance 1.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Sord) oxidoreductase activity (Sord) cilium (Sord)
cellular_component (Sord)
Anatomy Link Frequency
blood 1
Liver 1
nerve 1
bile 1
Sord (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Bile 6 100.00 Very High Very High Very High
Paracetamol 39 99.98 Very High Very High Very High
halothane 3 99.52 Very High Very High Very High
anesthesia 5 99.12 Very High Very High Very High
alcohol 1 98.44 Very High Very High Very High
Sciatic nerve 1 70.80 Quite High
Inflammation 4 64.72 Quite High
isoflurane 2 58.88 Quite High
Angina 5 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 10 100.00 Very High Very High Very High
Gallstones 1 100.00 Very High Very High Very High
Hepatotoxicity 9 99.48 Very High Very High Very High
Neuropathic Pain 1 99.40 Very High Very High Very High
Disorder Of Lipid Metabolism 6 96.80 Very High Very High Very High
Diabetes Mellitus 8 87.00 High High
Experimental Diabetes Mellitus 1 83.92 Quite High
Diabetes Complications 1 80.20 Quite High
Hyperplasia 2 79.48 Quite High
Aging 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Liver necrosis and an increase of serum sorbitol dehydrogenase activity can be produced in rats by halothane anesthesia (1% v/v in oxygen) following pretreatment with polychlorinated biphenyls.
Gene_expression (produced) of sorbitol dehydrogenase in Liver associated with anesthesia, hepatotoxicity and halothane
1) Confidence 0.78 Published 1982 Journal Anaesthesist Section Abstract Doc Link 6807128 Disease Relevance 0.25 Pain Relevance 0.30
Both doses of acetaminophen produced significant elevations of serum alanine aminotransferase (ALT) and sorbitol dehydrogenase (SDH) activities in 4-month-old rats.
Gene_expression (produced) of sorbitol dehydrogenase associated with paracetamol
2) Confidence 0.50 Published 1988 Journal Drug Chem Toxicol Section Abstract Doc Link 3181038 Disease Relevance 0.24 Pain Relevance 0.42
To identify the polyol pathway step most relevant to complications, particularly neuropathy, we compared the biochemical effects of a sorbitol dehydrogenase inhibitor, WAY-135706, (250 mg.kg-1.day-1) and an ARI, WAY-121509, (10 mg.kg-1.day-1) on a variety of tissues, and their effects on nerve perfusion and conduction velocity.
Gene_expression (effects) of sorbitol dehydrogenase in nerve associated with neuropathic pain
3) Confidence 0.49 Published 1997 Journal Diabetologia Section Abstract Doc Link 9084964 Disease Relevance 0.56 Pain Relevance 0.04
Clinical biochemistry values analyzed were: serum aspartate aminotransferase, serum alanine aminotransferase, sorbitol dehydrogenase, alkaline phosphatase, total bilirubin, blood urea nitrogen, blood creatinine, total cholesterol, triglycerides, fasting glucose, total serum protein, albumin, globulin, calcium, inorganic phosphorus, sodium, potassium, and chloride.
Gene_expression (aminotransferase) of sorbitol dehydrogenase in blood associated with disorder of lipid metabolism
4) Confidence 0.21 Published 2009 Journal Nutr J Section Body Doc Link PMC2633017 Disease Relevance 0.15 Pain Relevance 0.17
These included indicators of liver injury (Alanine Aminotransferase [ALT] and Aspartate aminotransferase [AST]), Sorbitol dehydrogenase [SDH], cholesterol levels, indication of renal injury (urea nitrogen [BUN]), assessment of cholestasis – bile flow interruption (total bile acids [TBA], Creatine [Creat], Alkaline Phosphatase [ALP]), total protein (TP) and albumin (ALB) levels.
Gene_expression (levels) of Sorbitol dehydrogenase in bile associated with bile, injury and gallstones
5) Confidence 0.16 Published 2007 Journal BMC Syst Biol Section Body Doc Link PMC1839893 Disease Relevance 0.68 Pain Relevance 0.28
Doses were selected to produce comparable peak serum malate dehydrogenase, sorbitol dehydrogenase, and SGPT activities.
Gene_expression (produce) of sorbitol dehydrogenase
6) Confidence 0.03 Published 1986 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 3787616 Disease Relevance 0.43 Pain Relevance 0.15

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