INT356372

Context Info Confidence 0.57 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.23 Pain Relevance 0.07

plasma membrane (Utrn) nucleus (Utrn) cytoplasm (Utrn)

Anatomy Link Frequency muscle 1 Utrn (Mus musculus)

Pain Link Frequency Relevance Heat fibrosis 72 67.96 Inflammation 8 66.20 imagery 12 5.00 Calcium channel 4 5.00 cytokine 2 5.00 tolerance 2 5.00 Angina 2 5.00 antagonist 2 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 12 99.04 Muscular Dystrophy 280 89.40 Cardiomyopathy 126 86.88 Congenital Anomalies 12 86.64 Fibrosis 86 67.96 INFLAMMATION 8 66.20 Myocardial Infarction 12 64.40 Stress 16 54.76 Duchenne Muscular Dystrophy 40 40.80 Dilated Cardiomyopathy 36 22.28

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The loss of utrophin has no effect on the phenotype of mice in isolation, as dystrophin is the major structural protein of the muscle fibres.

Negative_regulation (loss) of utrophin in muscle

1) Confidence 0.57 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC3024556 Disease Relevance 0.41 Pain Relevance 0

Whereas it appears that dystrophin is able to fully compensate for the loss of utrophin in the single utrophin knockout mouse, the opposite is not true as there is significant dysfunction in the mdx even if it takes longer to become manifest, so utrophin is not able to fully compensate for the loss of dystrophin.

Negative_regulation (loss) of utrophin associated with targeted disruption

2) Confidence 0.41 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC3024556 Disease Relevance 0.82 Pain Relevance 0.07

General Comments

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