INT356372

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Context Info
Confidence 0.57
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.23
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Utrn) nucleus (Utrn) cytoplasm (Utrn)
Anatomy Link Frequency
muscle 1
Utrn (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 72 67.96 Quite High
Inflammation 8 66.20 Quite High
imagery 12 5.00 Very Low Very Low Very Low
Calcium channel 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 12 99.04 Very High Very High Very High
Muscular Dystrophy 280 89.40 High High
Cardiomyopathy 126 86.88 High High
Congenital Anomalies 12 86.64 High High
Fibrosis 86 67.96 Quite High
INFLAMMATION 8 66.20 Quite High
Myocardial Infarction 12 64.40 Quite High
Stress 16 54.76 Quite High
Duchenne Muscular Dystrophy 40 40.80 Quite Low
Dilated Cardiomyopathy 36 22.28 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The loss of utrophin has no effect on the phenotype of mice in isolation, as dystrophin is the major structural protein of the muscle fibres.
Negative_regulation (loss) of utrophin in muscle
1) Confidence 0.57 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC3024556 Disease Relevance 0.41 Pain Relevance 0
Whereas it appears that dystrophin is able to fully compensate for the loss of utrophin in the single utrophin knockout mouse, the opposite is not true as there is significant dysfunction in the mdx even if it takes longer to become manifest, so utrophin is not able to fully compensate for the loss of dystrophin.
Negative_regulation (loss) of utrophin associated with targeted disruption
2) Confidence 0.41 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC3024556 Disease Relevance 0.82 Pain Relevance 0.07

General Comments

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