INT356374

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Context Info
Confidence 0.07
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.53
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Mib2) signal transduction (Mib2) ligase activity (Mib2)
cytoplasm (Mib2) signal transducer activity (Mib2)
Anatomy Link Frequency
heart 1
Mib2 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 108 60.60 Quite High
imagery 18 5.00 Very Low Very Low Very Low
Inflammation 12 5.00 Very Low Very Low Very Low
Calcium channel 6 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Angina 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Duchenne Muscular Dystrophy 60 99.84 Very High Very High Very High
Dilated Cardiomyopathy 54 98.16 Very High Very High Very High
Myocardial Infarction 18 97.60 Very High Very High Very High
Muscular Dystrophy 420 95.92 Very High Very High Very High
Fibrosis 129 94.28 High High
Shock 3 80.40 Quite High
Disease 9 75.68 Quite High
Frailty 6 69.12 Quite High
Contracture 9 64.64 Quite High
Muscle Weakness 6 62.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In BMD the deletions usually do not cause a shift in the reading frame; this tends to produce a functional but truncated version of the dystrophin protein.
Gene_expression (produce) of dystrophin protein associated with duchenne muscular dystrophy
1) Confidence 0.07 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC3024556 Disease Relevance 1.18 Pain Relevance 0
The disorder is caused by mutations in the dystrophin gene, usually deletions or point mutations that lead to a shift in the reading frame and produce a stop codon, thus causing the complete loss or very reduced and deficient synthesis of dystrophin protein, which forms an integral part of the dystrophin-glycoprotein complex (DGC) [3].
Gene_expression (synthesis) of dystrophin protein
2) Confidence 0.07 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC3024556 Disease Relevance 0.40 Pain Relevance 0
Specifically, the absence of the dystrophin protein in the heart results in the development of a DCM [10].
Neg (absence) Gene_expression (absence) of dystrophin protein in heart associated with dilated cardiomyopathy
3) Confidence 0.06 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC3024556 Disease Relevance 0.95 Pain Relevance 0.03

General Comments

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