INT3564

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Context Info
Confidence 0.58
First Reported 1975
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 14
Disease Relevance 15.38
Pain Relevance 3.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Aip) cytosol (Aip) nucleolus (Aip)
plasma membrane (Aip) nucleus (Aip) cytoplasm (Aip)
Anatomy Link Frequency
pancreas 1
neurons 1
ampulla 1
parenchyma 1
Aip (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 47 100.00 Very High Very High Very High
alcohol 2 100.00 Very High Very High Very High
Abeta 12 99.62 Very High Very High Very High
corticosteroid 104 98.84 Very High Very High Very High
Inflammation 32 98.56 Very High Very High Very High
Eae 1 98.44 Very High Very High Very High
Pain 19 89.16 High High
imagery 94 85.20 High High
abdominal pain 33 82.76 Quite High
fibrosis 52 81.52 Quite High
Disease Link Frequency Relevance Heat
Pancreatitis 638 100.00 Very High Very High Very High
Disease 142 99.96 Very High Very High Very High
Appetite Loss 1 99.84 Very High Very High Very High
Ductal Carcinoma 5 99.12 Very High Very High Very High
INFLAMMATION 40 98.56 Very High Very High Very High
Thyroid Disease 1 96.76 Very High Very High Very High
Pressure And Volume Under Development 9 96.00 Very High Very High Very High
Diabetes Mellitus 11 95.40 Very High Very High Very High
Malignant Neoplastic Disease 28 90.56 High High
Drug Induced Neurotoxicity 4 89.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVE: With an increase in autoimmune pancreatitis (AIP) being reported, the focal type of AIP, which shows localized narrowing of the main pancreatic duct and focal swelling of the pancreas, has recently been recognized.
Positive_regulation (increase) of AIP in pancreas associated with pressure and volume under development and pancreatitis
1) Confidence 0.58 Published 2008 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 18158696 Disease Relevance 0.94 Pain Relevance 0.22
Recently, as awareness of AIP is increasing, more cases are being reported.
Positive_regulation (increasing) of AIP associated with chronic pancreatitis
2) Confidence 0.40 Published 2007 Journal J. Gastroenterol. Section Abstract Doc Link 17520223 Disease Relevance 0.76 Pain Relevance 0.68
However, the accumulation of many AIP cases shows that the concept of AIP has changed slightly to include extrapancreatic lesions and associated disorders, which suggests that the current diagnostic criteria are becoming inadequate.
Positive_regulation (accumulation) of AIP associated with pancreatitis
3) Confidence 0.35 Published 2006 Journal J Gastroenterol Section Body Doc Link PMC2780630 Disease Relevance 1.48 Pain Relevance 0.04
High activities of serum AIP, LAP and gamma-GTP were observed.
Positive_regulation (activities) of AIP
4) Confidence 0.18 Published 1988 Journal Hokkaido Igaku Zasshi Section Abstract Doc Link 3283015 Disease Relevance 1.00 Pain Relevance 0.13
Classification as lobulocentric AIP (n=11), ductocentric AIP (n=15), and mixed AIP (n=12) did not correlate with extent of patchiness (P=0.92) or with the volume of spared parenchyma (P=1.0).
Positive_regulation (ductocentric) of AIP in parenchyma associated with pancreatitis
5) Confidence 0.17 Published 2008 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 18779731 Disease Relevance 1.04 Pain Relevance 0.04
This current report demonstrates that while pediatric AIP/ISD is very similar to adult AIP/ISD, it is not identical.
Positive_regulation (pediatric) of AIP associated with pancreatitis and disease
6) Confidence 0.10 Published 2011 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC3022838 Disease Relevance 1.73 Pain Relevance 0.22
This current report demonstrates that while pediatric AIP/ISD is very similar to adult AIP/ISD, it is not identical.
Positive_regulation (adult) of AIP associated with pancreatitis and disease
7) Confidence 0.10 Published 2011 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC3022838 Disease Relevance 1.84 Pain Relevance 0.22
In most cases of AIP, patients respond fully to a single course of corticosteroids [2,3,25]; however, some patients with AIP, and especially those with extrapancreatic manifestations (including our patient), are unable to fully wean off of corticosteroids [22,25,27].
Positive_regulation (respond) of AIP associated with corticosteroid and pancreatitis
8) Confidence 0.09 Published 2011 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC3022838 Disease Relevance 1.48 Pain Relevance 0.29
Treatment of AIP
Positive_regulation (Treatment) of AIP associated with pancreatitis
9) Confidence 0.09 Published 2011 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC3022838 Disease Relevance 1.60 Pain Relevance 0.41
Although an overlap was present between the groups, the overall inflammation and number of plasma cells in and around the ampulla was significantly increased in AIP compared with CP and IDC.
Positive_regulation (increased) of AIP in ampulla associated with ductal carcinoma, inflammation, pancreatitis and chronic pancreatitis
10) Confidence 0.08 Published 2008 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 18779730 Disease Relevance 1.63 Pain Relevance 0.42
In western countries this is associated with the known increase in alcohol consumption and AIP.
Positive_regulation (increase) of AIP associated with alcohol
11) Confidence 0.07 Published 1975 Journal Am. J. Gastroenterol. Section Abstract Doc Link 808121 Disease Relevance 1.13 Pain Relevance 0.35
Three separate risk adjusted HCQI rates are thus computed, based on which method is used for adjustment: the expected rate based on the client covariates only (CC), on client covariates plus AIP (+AIP) and on client covariates plus CMI (+CMI).
Positive_regulation (covariates) of AIP
12) Confidence 0.06 Published 2005 Journal BMC Health Serv Res Section Body Doc Link PMC548266 Disease Relevance 0 Pain Relevance 0
Three separate risk adjusted HCQI rates are thus computed, based on which method is used for adjustment: the expected rate based on the client covariates only (CC), on client covariates plus AIP (+AIP) and on client covariates plus CMI (+CMI).
Positive_regulation (covariates) of AIP
13) Confidence 0.06 Published 2005 Journal BMC Health Serv Res Section Body Doc Link PMC548266 Disease Relevance 0 Pain Relevance 0
While these inhibitors significantly attenuated Abeta peptide-triggered activation of caspase-2 and caspase-3, and AIP significantly decreased the degree of tau phosphorylation of the Abeta peptide-treated neurons at early time, they could elicit partial neuroprotection only.
Positive_regulation (activation) of AIP in neurons associated with eae and abeta
14) Confidence 0.01 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15090032 Disease Relevance 0.76 Pain Relevance 0.61

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