INT35642

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Context Info
Confidence 0.26
First Reported 1988
Last Reported 2010
Negated 3
Speculated 2
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 3.85
Pain Relevance 1.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

BPIFA4P (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 9 98.92 Very High Very High Very High
narcan 1 98.36 Very High Very High Very High
Dismenorea 1 95.68 Very High Very High Very High
opiate 5 95.44 Very High Very High Very High
Morphine 2 93.40 High High
Codeine 3 86.64 High High
Pain 17 67.16 Quite High
tolerance 1 60.72 Quite High
Neuropathic pain 4 7.32 Low Low
ischemia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 144 99.28 Very High Very High Very High
Cough 7 95.96 Very High Very High Very High
Reprotox - General 1 1 95.68 Very High Very High Very High
Ovarian Cysts 1 94.68 High High
Disease 12 90.04 High High
Neuropathic Pain 76 88.96 High High
Injury 8 69.24 Quite High
Lens Subluxation 7 68.56 Quite High
Pain 17 67.16 Quite High
Glaucoma 10 65.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In all cases, the LH surge observed in the control cycle was blunted by chlormadinone acetate, while the base gonadotropin levels were not modified.
Neg (not) Regulation (modified) of base
1) Confidence 0.26 Published 1994 Journal Contracept Fertil Sex (Paris) Section Abstract Doc Link 12287767 Disease Relevance 0.19 Pain Relevance 0.13
However, there was no significant drug effect on either the base-line Rrs or its increase after capsaicin.
Neg (no) Regulation (effect) of base-line associated with qutenza
2) Confidence 0.15 Published 1988 Journal J. Appl. Physiol. Section Abstract Doc Link 3182481 Disease Relevance 0.56 Pain Relevance 1.40
By direct sequencing the 65 exons of FBN1, we identified a novel base change, C>T, at position 2860 of cDNA, replacing arginine acid with cysteine at codon 954 (Figure 2A).
Regulation (change) of base
3) Confidence 0.07 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2443751 Disease Relevance 0.29 Pain Relevance 0
This indicates that a statin treatment does not significantly influence sphingoid base levels.
Neg (not) Regulation (influence) of base
4) Confidence 0.05 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2931514 Disease Relevance 0.51 Pain Relevance 0
Thus an impact of statin treatment on the sphingoid base levels cannot be completely excluded.
Regulation (impact) of base
5) Confidence 0.04 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2931514 Disease Relevance 0.60 Pain Relevance 0
Within this framework of evidence, we were interested to investigate whether sphingoid base levels are altered in patients with an impaired glucose metabolism such as that seen in diabetes mellitus.


Spec (whether) Regulation (altered) of base associated with diabetes mellitus
6) Confidence 0.02 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2931514 Disease Relevance 0.70 Pain Relevance 0.07
Since serine and alanine metabolism is functionally linked to carbohydrate metabolism by their precursors 3-phosphoglycerate and pyruvate, we were interested to see whether the levels of certain sphingoid base metabolites are altered in patients with diabetes.


Spec (whether) Regulation (altered) of base associated with diabetes mellitus
7) Confidence 0.02 Published 2010 Journal Lipids Health Dis Section Abstract Doc Link PMC2931514 Disease Relevance 0.99 Pain Relevance 0

General Comments

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