INT35643

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Context Info
Confidence 0.67
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 10
Disease Relevance 4.87
Pain Relevance 2.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
eyes 1
BPIFA4P (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 1 99.30 Very High Very High Very High
Morphine 10 98.40 Very High Very High Very High
Central nervous system 3 98.36 Very High Very High Very High
Codeine 3 96.48 Very High Very High Very High
qutenza 9 95.60 Very High Very High Very High
Pain 1 93.28 High High
opiate 5 81.84 Quite High
cocaine 5 79.56 Quite High
narcan 1 65.04 Quite High
nud 8 37.12 Quite Low
Disease Link Frequency Relevance Heat
Reticulocytosis 1 99.78 Very High Very High Very High
Acid Base Imbalance 272 99.40 Very High Very High Very High
Headache 1 99.30 Very High Very High Very High
Disease 263 98.74 Very High Very High Very High
Cough 7 98.60 Very High Very High Very High
Dystonia 1 98.34 Very High Very High Very High
Syndrome 5 95.84 Very High Very High Very High
Chronic Renal Failure 256 95.40 Very High Very High Very High
Pain 1 93.28 High High
Hypertension 12 92.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Analysis of literature and the authors' own data suggest that laser-induced occupational disease may be diagnosed in following disorders on the part of: vision--deterioration of light and colour perception, pain and feeling of burning in the eyes; central nervous system--vegetative dysfunction, hypo- or hypertonic neuro-asthenic syndrome manifesting in weakness and fatiguability; cardiovascular system--cardialgias, hypo- or hypertonic neurocirculatory dystonia, hypertonic disease, general weakness, headache; blood--reticulocytosis; enzymes--increase of base phosphatase activity in blood.
Positive_regulation (increase) of base in eyes associated with pain, reticulocytosis, syndrome, disease, occupational diseases, central nervous system, headache and dystonia
1) Confidence 0.67 Published 1994 Journal Lik. Sprava Section Abstract Doc Link 8073724 Disease Relevance 0.75 Pain Relevance 0.24
There was an isotopic fractionation against 15N during the acetylation of morphine base to heroin base, but this effect was not expressed since all of the heroin base was precipitated during the manufacturing process.
Positive_regulation (precipitated) of base associated with morphine
2) Confidence 0.49 Published 2005 Journal J. Forensic Sci. Section Abstract Doc Link 16382825 Disease Relevance 0 Pain Relevance 0.81
In contrast, both drugs increased base-line Rrs by 24% (16-44) and 13% (3-23), respectively, and significantly reduced the increase in Rrs after inhaled capsaicin (P less than 0.05).
Positive_regulation (increased) of base-line associated with qutenza
3) Confidence 0.26 Published 1988 Journal J. Appl. Physiol. Section Abstract Doc Link 3182481 Disease Relevance 0.57 Pain Relevance 1.25
The first step of BER is the removal of the damaged base by a substrate-specific DNA glycosylase, generating an abasic (AP) site, which is cleaved by an AP lyase or AP endonuclease (i.e.
Positive_regulation (removal) of base
4) Confidence 0.11 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC2018628 Disease Relevance 0.66 Pain Relevance 0.05
The first step of BER is the removal of the damaged base by a substrate-specific DNA glycosylase, generating an abasic (AP) site, which is cleaved by an AP lyase or AP endonuclease (i.e.
Positive_regulation (damaged) of base
5) Confidence 0.11 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC2018628 Disease Relevance 0.65 Pain Relevance 0.05
We recommend administering sufficient base to raise serum [HCO3?]
Positive_regulation (administering) of base
6) Confidence 0.07 Published 2010 Journal Pediatr Nephrol Section Body Doc Link PMC2991191 Disease Relevance 0.70 Pain Relevance 0
We recommend administering sufficient base to raise serum [HCO3?]
Positive_regulation (sufficient) of base
7) Confidence 0.07 Published 2010 Journal Pediatr Nephrol Section Body Doc Link PMC2991191 Disease Relevance 0.70 Pain Relevance 0
If the latter preparation is not available, base administration might have to be increased to prevent or treat metabolic acidosis.
Positive_regulation (increased) of base associated with acid base imbalance
8) Confidence 0.06 Published 2010 Journal Pediatr Nephrol Section Body Doc Link PMC2991191 Disease Relevance 0.48 Pain Relevance 0
These complications can be avoided by the concomitant administration of diuretics or the use of calcium carbonate or calcium citrate to provide the base.
Positive_regulation (provide) of base
9) Confidence 0.06 Published 2010 Journal Pediatr Nephrol Section Body Doc Link PMC2991191 Disease Relevance 0.36 Pain Relevance 0
FGS were derived from Gene Ontology (GO) [20], the KEGG pathways database [21], and the Ingenuity Pathways Knowledge Base (ING) (Ingenuity Systems, Redwood City, CA).
Positive_regulation (derived) of Base
10) Confidence 0.02 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2346558 Disease Relevance 0 Pain Relevance 0

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