INT35643

Context Info Confidence 0.67 First Reported 1988 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 7 Total Number 10 Disease Relevance 4.87 Pain Relevance 2.39

Anatomy Link Frequency eyes 1 BPIFA4P (Homo sapiens)

Pain Link Frequency Relevance Heat headache 1 99.30 Morphine 10 98.40 Central nervous system 3 98.36 Codeine 3 96.48 qutenza 9 95.60 Pain 1 93.28 opiate 5 81.84 cocaine 5 79.56 narcan 1 65.04 nud 8 37.12

Disease Link Frequency Relevance Heat Reticulocytosis 1 99.78 Acid Base Imbalance 272 99.40 Headache 1 99.30 Disease 263 98.74 Cough 7 98.60 Dystonia 1 98.34 Syndrome 5 95.84 Chronic Renal Failure 256 95.40 Pain 1 93.28 Hypertension 12 92.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Analysis of literature and the authors' own data suggest that laser-induced occupational disease may be diagnosed in following disorders on the part of: vision--deterioration of light and colour perception, pain and feeling of burning in the eyes; central nervous system--vegetative dysfunction, hypo- or hypertonic neuro-asthenic syndrome manifesting in weakness and fatiguability; cardiovascular system--cardialgias, hypo- or hypertonic neurocirculatory dystonia, hypertonic disease, general weakness, headache; blood--reticulocytosis; enzymes--increase of base phosphatase activity in blood.

Positive_regulation (increase) of base in eyes associated with pain, reticulocytosis, syndrome, disease, occupational diseases, central nervous system, headache and dystonia

1) Confidence 0.67 Published 1994 Journal Lik. Sprava Section Abstract Doc Link 8073724 Disease Relevance 0.75 Pain Relevance 0.24

There was an isotopic fractionation against 15N during the acetylation of morphine base to heroin base, but this effect was not expressed since all of the heroin base was precipitated during the manufacturing process.

Positive_regulation (precipitated) of base associated with morphine

2) Confidence 0.49 Published 2005 Journal J. Forensic Sci. Section Abstract Doc Link 16382825 Disease Relevance 0 Pain Relevance 0.81

In contrast, both drugs increased base-line Rrs by 24% (16-44) and 13% (3-23), respectively, and significantly reduced the increase in Rrs after inhaled capsaicin (P less than 0.05).

Positive_regulation (increased) of base-line associated with qutenza

3) Confidence 0.26 Published 1988 Journal J. Appl. Physiol. Section Abstract Doc Link 3182481 Disease Relevance 0.57 Pain Relevance 1.25

The first step of BER is the removal of the damaged base by a substrate-specific DNA glycosylase, generating an abasic (AP) site, which is cleaved by an AP lyase or AP endonuclease (i.e.

Positive_regulation (removal) of base

4) Confidence 0.11 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC2018628 Disease Relevance 0.66 Pain Relevance 0.05

The first step of BER is the removal of the damaged base by a substrate-specific DNA glycosylase, generating an abasic (AP) site, which is cleaved by an AP lyase or AP endonuclease (i.e.

Positive_regulation (damaged) of base

5) Confidence 0.11 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC2018628 Disease Relevance 0.65 Pain Relevance 0.05

We recommend administering sufficient base to raise serum [HCO3?]

Positive_regulation (administering) of base

6) Confidence 0.07 Published 2010 Journal Pediatr Nephrol Section Body Doc Link PMC2991191 Disease Relevance 0.70 Pain Relevance 0

We recommend administering sufficient base to raise serum [HCO3?]

Positive_regulation (sufficient) of base

7) Confidence 0.07 Published 2010 Journal Pediatr Nephrol Section Body Doc Link PMC2991191 Disease Relevance 0.70 Pain Relevance 0

If the latter preparation is not available, base administration might have to be increased to prevent or treat metabolic acidosis.

Positive_regulation (increased) of base associated with acid base imbalance

8) Confidence 0.06 Published 2010 Journal Pediatr Nephrol Section Body Doc Link PMC2991191 Disease Relevance 0.48 Pain Relevance 0

These complications can be avoided by the concomitant administration of diuretics or the use of calcium carbonate or calcium citrate to provide the base.

Positive_regulation (provide) of base

9) Confidence 0.06 Published 2010 Journal Pediatr Nephrol Section Body Doc Link PMC2991191 Disease Relevance 0.36 Pain Relevance 0

FGS were derived from Gene Ontology (GO) [20], the KEGG pathways database [21], and the Ingenuity Pathways Knowledge Base (ING) (Ingenuity Systems, Redwood City, CA).

Positive_regulation (derived) of Base

10) Confidence 0.02 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2346558 Disease Relevance 0 Pain Relevance 0

General Comments

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